prikaz prve stranice dokumenta Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections
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Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections
International Journal of Surgery, 54 (2018), Pt A; 248-253. https://doi.org/doi:10.1016/j.ijsu.2018.05.001
Rakić, Mislav; Patrlj, Leonardo; Amić, Fedor; Aralica, Gorana; Grgurević, Ivica

Citirajte ovaj rad

Rakić, M., Patrlj, L., Amić, F., Aralica, G. i Grgurević, I. (2018). Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections. International Journal of Surgery, 54. (Pt A), 248-253. doi: doi:10.1016/j.ijsu.2018.05.001

Rakić, Mislav, et al. "Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections." International Journal of Surgery, vol. 54, br. Pt A, 2018, str. 248-253. https://doi.org/doi:10.1016/j.ijsu.2018.05.001

Rakić, Mislav, Leonardo Patrlj, Fedor Amić, Gorana Aralica i Ivica Grgurević. "Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections." International Journal of Surgery 54, br. Pt A (2018): 248-253. https://doi.org/doi:10.1016/j.ijsu.2018.05.001

Rakić, M., et al. (2018) 'Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections', International Journal of Surgery, 54(Pt A), str. 248-253. doi: doi:10.1016/j.ijsu.2018.05.001

Rakić M, Patrlj L, Amić F, Aralica G, Grgurević I. Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections. International Journal of Surgery [Internet]. 06.2018. [pristupljeno 12.04.2024.];54(Pt A):248-253. doi: doi:10.1016/j.ijsu.2018.05.001

M. Rakić, L. Patrlj, F. Amić, G. Aralica i I. Grgurević, "Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections", International Journal of Surgery, vol. 54, br. Pt A, str. 248-253, Lipanj 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:565127. [Citirano: 12.04.2024.]

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Naslov (engleski)Comparison of hepatoprotective effect from ischemia-reperfusion injury of remote ischemic preconditioning of the liver vs local ischemic preconditioning of the liver during human liver resections
AutorMislav Rakić
AutorLeonardo Patrlj
AutorFedor Amić
AutorGorana Aralica
AutorIvica Grgurević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: To compare and evaluate the hepatoprotective effect of remote ischemic preconditioning (RIPC) with local ischemic preconditioning (LIPC) of the liver during human liver resections. ----- METHODS: A prospective, single-centre, randomised control trial was conducted in the Clinical Hospital "***" from April 2017 to January 2018. A total of 60 patients, who underwent liver resection due to colorectal cancer liver metastasis, were randomised to one of three study arms: 1) a RIPC group, 2) an LIPC group and 3) a control group (CG) in which no ischemic preconditioning was done before liver resection. The hepatoprotective effect was evaluated by comparing serum transaminase levels, bilirubin levels, albumin, and protein levels, coagulograms and through pathohistological analysis. The trial was registered on ClinicalTrials.gov (NCT****). ----- RESULTS: Significant differences were found in serum levels of liver transaminases and bilirubin levels between the groups, the highest level in the CG and the lowest level in the LIPC group. Levels of cholinesterase were also significantly higher in the LIPC group. Pathohistological findings graded by the Rodriguez score showed favourable changes in the LIPC and RIPC groups versus the CG. ----- CONCLUSION: Strong evidence supports the hepatoprotective effect of RIPC and LIPC preconditioning from an ischemia-reperfusion injury of the liver. Better synthetic liver function preservation in these two groups supports this conclusion.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaInternational Journal of Surgery
Brojčani podacivol. 54, br. Pt A, str. 248-253
p-ISSN1743-9191
DOIhttps://doi.org/doi:10.1016/j.ijsu.2018.05.001
URN:NBNurn:nbn:hr:105:565127
Datum objave publikacije2018-06
URL dokumentahttp://doi.org/10.1016/j.ijsu.2018.05.001
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:18:10