prikaz prve stranice dokumenta Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits
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Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits
JBMR Plus, 3 (2018), 5; e10085. https://doi.org/10.1002/jbm4.10085
Grgurević, Lovorka; Oppermann, Hermann; Pećin, Marko; Erjavec, Igor; Capak, Hrvoje; Pauk, Martina; Karlović, Sven; Kufner, Vera; Lipar, Marija; Bubić Špoljar, Jadranka; Bordukalo-Nikšić, Tatjana; Matičić, Dražen; Perić, Mihaela; Windhager, Reinhard; Sampath, T Kuber; Vukičević, Slobodan Više autora...

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Grgurević, L., Oppermann, H., Pećin, M., Erjavec, I., Capak, H., Pauk, M. ... Vukičević, S. (2018). Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits. JBMR Plus, 3. (5). doi: 10.1002/jbm4.10085

Grgurević, Lovorka, et al. "Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits." JBMR Plus, vol. 3, br. 5, 2018. https://doi.org/10.1002/jbm4.10085

Grgurević, Lovorka, Hermann Oppermann, Marko Pećin, Igor Erjavec, Hrvoje Capak, Martina Pauk, Sven Karlović, et al. "Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits." JBMR Plus 3, br. 5 (2018). https://doi.org/10.1002/jbm4.10085

Grgurević, L., et al. (2018) 'Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits', JBMR Plus, 3(5). doi: 10.1002/jbm4.10085

Grgurević L, Oppermann H, Pećin M, Erjavec I, Capak H, Pauk M, i sur.. Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits. JBMR Plus [Internet]. 2018. [pristupljeno 15.04.2024.];3(5). doi: 10.1002/jbm4.10085

L. Grgurević, et al., "Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits", JBMR Plus, vol. 3, br. 5, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:915117. [Citirano: 15.04.2024.]

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Naslov (engleski)Recombinant human bone morphogenetic protein 6 delivered within autologous blood coagulum restores critical size segmental defects of ulna in rabbits
AutorLovorka Grgurević
AutorHermann Oppermann
AutorMarko Pećin
AutorIgor Erjavec
AutorHrvoje Capak
AutorMartina Pauk
AutorSven Karlović
AutorVera Kufner
AutorMarija Lipar
AutorJadranka Bubić Špoljar
AutorTatjana Bordukalo-Nikšić
AutorDražen Matičić
AutorMihaela Perić
AutorReinhard Windhager
AutorT Kuber Sampath
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BMP2 and BMP7, which use bovine Achilles tendon-derived absorbable collagen sponge and bovine bone collagen as scaffold, respectively, have been approved as bone graft substitutes for orthopedic and dental indications. Here, we describe an osteoinductive autologous bone graft substitute (ABGS) that contains recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) scaffold. The ABGS is created as an injectable or implantable coagulum gel with rhBMP6 binding tightly to plasma proteins within fibrin meshwork, as examined by dot-blot assays, and is released slowly as an intact protein over 6 to 8 days, as assessed by ELISA. The biological activity of ABGS was examined in vivo in rats (Rattus norvegicus) and rabbits (Oryctolagus cuniculus). In a rat subcutaneous implant assay, ABGS induced endochondral bone formation, as observed by histology and micro-CT analyses. In the rabbit ulna segmental defect model, a reproducible and robust bone formation with complete bridging and restoration of the defect was observed, which is dose dependent, as determined by radiographs, micro-CT, and histological analyses. In ABGS, ABC scaffold provides a permissive environment for bone induction and contributes to the use of lower doses of rhBMP6 compared with BMP7 in bovine bone collagen as scaffold. The newly formed bone undergoes remodeling and establishes cortices uniformly that is restricted to implant site by bridging with host bone. In summary, ABC carrier containing rhBMP6 may serve as an osteoinductive autologous bone graft substitute for several orthopedic applications that include delayed and nonunion fractures, anterior and posterior lumbar interbody fusion, trauma, and nonunions associated with neurofibromatosis type I.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJBMR Plus
Brojčani podacivol. 3, br. 5, e10085
p-ISSN2473-4039
DOIhttps://doi.org/10.1002/jbm4.10085
URN:NBNurn:nbn:hr:105:915117
Datum objave publikacije2018
URL dokumentahttps://doi.org/10.1002/jbm4.10085
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:21:21