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Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology
Contact Dermatitis, 76 (2017), 5; 287-295. https://doi.org/10.1111/cod.12770
Koppes, Sjors A.; Ljubojević Hadžavdić, Suzana; Jakasa, Ivone; Franceschi, Nika; Riethmüller, Christoph; Jurakić Tončic, Ružica; Marinović, Branka; Raj, Nidhin; Rawlings, Anthony V.; Voegeli, Rainer; Lane, Majella E.; Haftek, Marek; Frings-Dresen, Monique H.W.; Rustemeyer, Thomas; Kezic, Sanja Više autora...

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Koppes, S. A., Ljubojević Hadžavdić, S., Jakasa, I., Franceschi, N., Riethmüller, C., Jurakić Tončic, R. ... Kezic, S. (2017). Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology. Contact Dermatitis, 76. (5), 287-295. doi: 10.1111/cod.12770

Koppes, Sjors A., et al. "Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology." Contact Dermatitis, vol. 76, br. 5, 2017, str. 287-295. https://doi.org/10.1111/cod.12770

Koppes, Sjors A., Suzana Ljubojević Hadžavdić, Ivone Jakasa, Nika Franceschi, Christoph Riethmüller, Ružica Jurakić Tončic, Branka Marinović, et al. "Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology." Contact Dermatitis 76, br. 5 (2017): 287-295. https://doi.org/10.1111/cod.12770

Koppes, S. A., et al. (2017) 'Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology', Contact Dermatitis, 76(5), str. 287-295. doi: 10.1111/cod.12770

Koppes SA, Ljubojević Hadžavdić S, Jakasa I, Franceschi N, Riethmüller C, Jurakić Tončic R, i sur.. Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology. Contact Dermatitis [Internet]. 05.2017. [pristupljeno 25.07.2024.];76(5):287-295. doi: 10.1111/cod.12770

S. A. Koppes, et al., "Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology", Contact Dermatitis, vol. 76, br. 5, str. 287-295, Svibanj 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:349615. [Citirano: 25.07.2024.]

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Naslov (engleski)Effect of allergens and irritants on levels of natural moisturizing factor and corneocyte morphology
AutorSjors A. Koppes
AutorSuzana Ljubojević Hadžavdić
AutorIvone Jakasa
AutorNika Franceschi
AutorChristoph Riethmüller
AutorRužica Jurakić Tončic
AutorBranka Marinović
AutorNidhin Raj
AutorAnthony V. Rawlings
AutorRainer Voegeli
AutorMajella E. Lane
AutorMarek Haftek
AutorMonique H.W. Frings-Dresen
AutorThomas Rustemeyer
AutorSanja Kezic
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: The irritant sodium lauryl sulfate (SLS) is known to cause a decrease in the stratum corneum level of natural moisturizing factor (NMF), which in itself is associated with changes in corneocyte surface topography. ----- OBJECTIVE: To explore this phenomenon in allergic contact dermatitis. ----- METHODS: Patch testing was performed on patients with previously positive patch test reactions to potassium dichromate (Cr), nickel sulfate (Ni), methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI), or p-phenylenediamine. Moreover, a control (pet.) patch and an irritant (SLS) patch were applied. After 3 days, the stratum corneum from tested sites was collected, and NMF levels and corneocyte morphology, expressed as the amount of circular nanosize objects, quantified according to the Dermal Texture Index (DTI), were determined. ----- RESULTS: Among allergens, only MCI/MI reduced NMF levels significantly, as did SLS. Furthermore, only MCI/MI caused remarkable changes at the microscopic level; the corneocytes were hexagonal-shaped with pronounced cell borders and a smoother surface. The DTI was increased after SLS exposure but not after allergen exposure. ----- CONCLUSIONS: MCI/MI significantly decreased NMF levels, similarly to SLS. The altered corneocyte morphology suggests that skin barrier damage plays a role in the pathogenesis of MCI/MI contact allergy. The DTI seems to differentiate reactions to SLS from those to the allergens tested, as SLS was the only agent that caused a DTI increase.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaContact Dermatitis
Brojčani podacivol. 76, br. 5, str. 287-295
p-ISSN0105-1873
DOIhttps://doi.org/10.1111/cod.12770
URN:NBNurn:nbn:hr:105:349615
Datum objave publikacije2017-05
URL dokumentahttps://doi.org/10.1111/cod.12770
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:21:30