prikaz prve stranice dokumenta Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer
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Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer
Scientific Reports, 9 (2019), 1; https://doi.org/10.1038/s41598-019-38797-z
Božinović, Ksenija; Sabol, Ivan; Dediol, Emil; Milutin Gašperov, Nina; Manojlović, Spomenka; Vojtechova, Zuzana; Tachezy, Ruth; Grce, Magdalena

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Božinović, K., Sabol, I., Dediol, E., Milutin Gašperov, N., Manojlović, S., Vojtechova, Z. ... Grce, M. (2019). Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer. Scientific Reports, 9. (1). doi: 10.1038/s41598-019-38797-z

Božinović, Ksenija, et al. "Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer." Scientific Reports, vol. 9, br. 1, 2019. https://doi.org/10.1038/s41598-019-38797-z

Božinović, Ksenija, Ivan Sabol, Emil Dediol, Nina Milutin Gašperov, Spomenka Manojlović, Zuzana Vojtechova, Ruth Tachezy i Magdalena Grce. "Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer." Scientific Reports 9, br. 1 (2019). https://doi.org/10.1038/s41598-019-38797-z

Božinović, K., et al. (2019) 'Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer', Scientific Reports, 9(1). doi: 10.1038/s41598-019-38797-z

Božinović K, Sabol I, Dediol E, Milutin Gašperov N, Manojlović S, Vojtechova Z, i sur.. Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer. Scientific Reports [Internet]. 19.02.2019. [pristupljeno 12.04.2024.];9(1). doi: 10.1038/s41598-019-38797-z

K. Božinović, et al., "Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer", Scientific Reports, vol. 9, br. 1, Veljača 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:805612. [Citirano: 12.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:805612
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Naslov (engleski)Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer
AutorKsenija Božinović
AutorIvan Sabol
AutorEmil Dediol
AutorNina Milutin Gašperov
AutorSpomenka Manojlović
AutorZuzana Vojtechova
AutorRuth Tachezy
AutorMagdalena Grce
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Head and neck cancer is the sixth most common malignancy worldwide, predominantly developing from squamous cell epithelia (HNSCC). The main HNSCC risk factors are tobacco, excessive alcohol use, and the presence of human papillomavirus (HPV). HPV positive (+) cancers are etiologically different from other HNSCC and often show better prognosis. The current knowledge regarding HNSCC miRNA profiles is still incomplete especially in the context of HPV+ cancer. Thus, we analyzed 61 freshly collected primary oral (OSCC) and oropharyngeal (OPSCC) SCC samples. HPV DNA and RNA was found in 21% cases. The Illumina whole-genome small-RNA profiling by next-generation sequencing was done on 22 samples and revealed 7 specific miRNAs to HPV+ OSCC, 77 to HPV+ OPSCC, and additional 3 shared with both; 51 miRNAs were specific to HPV− OPSCC, 62 to HPV− OSCC, and 31 shared with both. The results for 9 miRNAs (miR-9, -21, -29a, -100, -106b, -143 and -145) were assessed by reverse transcription-quantitative polymerase chain reaction on the whole study population. The data was additionally confirmed by reanalyzing publicly available miRNA sequencing Cancer Genome Atlas consortium (TCGA) HNSCC data. Cell signaling pathway analysis revealed differences between HPV+ and HPV− HNSCC. Our findings compared with literature data revealed extensive heterogeneity of miRNA deregulation with only several miRNAs consistently affected, and miR-9 being the most likely HPV related miRNA.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 9, br. 1
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-019-38797-z
URN:NBNurn:nbn:hr:105:805612
Datum objave publikacije2019-02-19
URL dokumentahttp://doi.org/10.1038/s41598-019-38797-z
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:27:54