prikaz prve stranice dokumenta Regulation of survivin isoform expression by GLI proteins in ovarian cancer
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Regulation of survivin isoform expression by GLI proteins in ovarian cancer
Cells, 8 (2019), 2; 128. https://doi.org/10.3390/cells8020128
Trnski, Diana; Gregorić, Maja; Levanat, Sonja; Ozretić, Petar; Rinčić, Nikolina; Vidaković, Tajana; Kalafatić, Držislav; Maurac, Ivana; Orešković, Slavko; Sabol, Maja; Musani, Vesna

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Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Vidaković, T. ... Musani, V. (2019). Regulation of survivin isoform expression by GLI proteins in ovarian cancer. Cells, 8. (2), 128. doi: 10.3390/cells8020128

Trnski, Diana, et al. "Regulation of survivin isoform expression by GLI proteins in ovarian cancer." Cells, vol. 8, br. 2, 2019, str. 128. https://doi.org/10.3390/cells8020128

Trnski, Diana, Maja Gregorić, Sonja Levanat, Petar Ozretić, Nikolina Rinčić, Tajana Vidaković, Držislav Kalafatić, et al. "Regulation of survivin isoform expression by GLI proteins in ovarian cancer." Cells 8, br. 2 (2019): 128. https://doi.org/10.3390/cells8020128

Trnski, D., et al. (2019) 'Regulation of survivin isoform expression by GLI proteins in ovarian cancer', Cells, 8(2), str. 128. doi: 10.3390/cells8020128

Trnski D, Gregorić M, Levanat S, Ozretić P, Rinčić N, Vidaković T, i sur.. Regulation of survivin isoform expression by GLI proteins in ovarian cancer. Cells [Internet]. 06.02.2019. [pristupljeno 18.04.2024.];8(2):128. doi: 10.3390/cells8020128

D. Trnski, et al., "Regulation of survivin isoform expression by GLI proteins in ovarian cancer", Cells, vol. 8, br. 2, str. 128, Veljača 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:649012. [Citirano: 18.04.2024.]

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Podaci o radu
Naslov (engleski)Regulation of survivin isoform expression by GLI proteins in ovarian cancer
AutorDiana Trnski
AutorMaja Gregorić
AutorSonja Levanat
AutorPetar Ozretić
AutorNikolina Rinčić
AutorTajana Vidaković
AutorDržislav Kalafatić
AutorIvana Maurac
AutorSlavko Orešković
AutorMaja Sabol
AutorVesna Musani
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Ovarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in late stages when treatment options are limited. Hedgehog-GLI (HH-GLI) signaling is a major developmental pathway involved in organogenesis and stem cell maintenance, and is activated in OC. One of its targets is survivin (BIRC5), an inhibitor of apoptosis protein (IAP) that plays a role in multiple processes, including proliferation and cell survival. We wanted to investigate the role of different GLI proteins in the regulation of survivin isoform expression (WT, 2α, 2B, 3B, and Dex3) in the SKOV-3 OC cell line. We demonstrated that survivin isoforms are downregulated in GLI1 and GLI2 knock-out cell lines, but not in the GLI3 knock-out. Treatment of GLI1 knock-out cells with GANT-61 shows an additional inhibitory effect on several isoforms. Additionally, we examined the expression of survivin isoforms in OC samples and the potential role of BIRC5 polymorphisms in isoform expression. Clinical samples showed the same pattern of survivin isoform expression as in the cell line, and several BIRC5 polymorphisms showed the correlation with isoform expression. Our results showed that survivin isoforms are regulated both by different GLI proteins and BIRC5 polymorphisms in OC.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCells
Brojčani podacivol. 8, br. 2, str. 128
p-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells8020128
URN:NBNurn:nbn:hr:105:649012
Datum objave publikacije2019-02-06
URL dokumentahttp://doi.org/10.3390/cells8020128
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:28:05