prikaz prve stranice dokumenta In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms
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In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms
Journal of Infection and Chemotherapy, 24 (2018), 12; 1016-1019. https://doi.org/10.1016/j.jiac.2018.06.001
Bedenić, Branka; Car, Haris; Slačanac, Domagoj; Sviben, Mario; Čačić, Marko; Lukić-Grlić, Amarela; Benčić, Ana; Šijak, Dorotea; Tripković, Marko; Beader, Nataša

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Bedenić, B., Car, H., Slačanac, D., Sviben, M., Čačić, M., Lukić Grlić, A. ... Beader, N. (2018). In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms. Journal of Infection and Chemotherapy, 24. (12), 1016-1019. doi: 10.1016/j.jiac.2018.06.001

Bedenić, Branka, et al. "In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms." Journal of Infection and Chemotherapy, vol. 24, br. 12, 2018, str. 1016-1019. https://doi.org/10.1016/j.jiac.2018.06.001

Bedenić, Branka, Haris Car, Domagoj Slačanac, Mario Sviben, Marko Čačić, Amarela Lukić Grlić, Ana Benčić, Dorotea Šijak, Marko Tripković i Nataša Beader. "In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms." Journal of Infection and Chemotherapy 24, br. 12 (2018): 1016-1019. https://doi.org/10.1016/j.jiac.2018.06.001

Bedenić, B., et al. (2018) 'In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms', Journal of Infection and Chemotherapy, 24(12), str. 1016-1019. doi: 10.1016/j.jiac.2018.06.001

Bedenić B, Car H, Slačanac D, Sviben M, Čačić M, Lukić Grlić A, i sur.. In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms. Journal of Infection and Chemotherapy [Internet]. 12.2018. [pristupljeno 20.12.2024.];24(12):1016-1019. doi: 10.1016/j.jiac.2018.06.001

B. Bedenić, et al., "In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms", Journal of Infection and Chemotherapy, vol. 24, br. 12, str. 1016-1019, Prosinac 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:513120. [Citirano: 20.12.2024.]

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Podaci o radu
Naslov (engleski)In vitro synergy and postantibiotic effect of colistin combinations with meropenem and vancomycin against Enterobacteriaceae with multiple carbapenem resistance mechanisms
AutorBranka Bedenić
AutorHaris Car
AutorDomagoj Slačanac
AutorMario Sviben
AutorMarko Čačić
AutorAmarela Lukić-Grlić
AutorAna Benčić
AutorDorotea Šijak
AutorMarko Tripković
AutorNataša Beader
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Aim: The aim of the study was to determine in vitro synergy and postantibiotic effect of colistin alone and combined with meropenem or vancomycin against Enterobacteriaceae producing multiple carbapenemases; combinations of two metallo-β-lactamases (MBL) or MBL with OXA-48. Colistin-resistant strain positive for OXA-48 was also included in the study. ----- Methods: The antibiotic susceptibility was tested by broth microdilution method. Synergy was tested by chequerboard, time-kill and 2-well method. PAE was determined by viable counting. ----- Results: The chequerboard analysis revealed synergy for colistin combination with meropenem in all isolates with FICI values ranging from 0.12 to 0.24. FICI values for combinations with vancomycin were below 0.5 indicating synergy in two out of four isolates. K. pneumoniae 609815 positive for OXA-48 and colistin resistant showed the most pronounced and consistent synergy effect with meropenem in both chequerboard and time-kill method. Synergy effect in time-kill curves, was observed for K pneumoniae 145846 with two MBLs and colistin resistant K. pneumoniae 609815 positive for OXA-48, with both combinations including meropenem and vancomycin. Colistin alone exhibited short postantibiotic effect (PAE) against all tested isolates. Meropenem markedly prolonged the PAE in two isolates in contrast to vancomycin which did not demonstrate significant effect on the duration of PAE. ----- Conclusions: The synergy effect and the duration of PAE was strain and antibiotic dependent but not related to the resistance gene content.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Infection and Chemotherapy
Brojčani podacivol. 24, br. 12, str. 1016-1019
p-ISSN1341-321X
DOIhttps://doi.org/10.1016/j.jiac.2018.06.001
URN:NBNurn:nbn:hr:105:513120
Datum objave publikacije2018-12
URL dokumentahttp://doi.org/10.1016/j.jiac.2018.06.001
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:30:35