prikaz prve stranice dokumenta Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients
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Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients
Scientific Reports, 9 (2019), 1; https://doi.org/10.1038/s41598-019-42937-w
Stryeck, Sarah; Gastrager, Michaela; Degoricija, Vesna; Trbušić, Matias; Potočnjak, Ines; Radulović, Bojana; Pregartner, Gudrun; Berghold, Andrea; Madl, Tobias; Frank, Saša

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Stryeck, S., Gastrager, M., Degoricija, V., Trbušić, M., Potočnjak, I., Radulović, B. ... Frank, S. (2019). Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients. Scientific Reports, 9. (1). doi: 10.1038/s41598-019-42937-w

Stryeck, Sarah, et al. "Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients." Scientific Reports, vol. 9, br. 1, 2019. https://doi.org/10.1038/s41598-019-42937-w

Stryeck, Sarah, Michaela Gastrager, Vesna Degoricija, Matias Trbušić, Ines Potočnjak, Bojana Radulović, Gudrun Pregartner, Andrea Berghold, Tobias Madl i Saša Frank. "Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients." Scientific Reports 9, br. 1 (2019). https://doi.org/10.1038/s41598-019-42937-w

Stryeck, S., et al. (2019) 'Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients', Scientific Reports, 9(1). doi: 10.1038/s41598-019-42937-w

Stryeck S, Gastrager M, Degoricija V, Trbušić M, Potočnjak I, Radulović B, i sur.. Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients. Scientific Reports [Internet]. 01.05.2019. [pristupljeno 28.04.2024.];9(1). doi: 10.1038/s41598-019-42937-w

S. Stryeck, et al., "Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients", Scientific Reports, vol. 9, br. 1, Svibanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:475691. [Citirano: 28.04.2024.]

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Naslov (engleski)Serum concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are associated with increased 3-month mortality in acute heart failure patients
AutorSarah Stryeck
AutorMichaela Gastrager
AutorVesna Degoricija
AutorMatias Trbušić
AutorInes Potočnjak
AutorBojana Radulović
AutorGudrun Pregartner
AutorAndrea Berghold
AutorTobias Madl
AutorSaša Frank
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Considering the already established relationship between the extent of the metabolic dysfunction and the severity of heart failure (HF), it is conceivable that the metabolomic profile of the serum may have a prognostic capacity for 3-month mortality in acute heart failure (AHF). Out of 152 recruited patients, 130 serum samples were subjected to the metabolomic analyses. The 3-month mortality rate was 24.6% (32 patients). Metabolomic profiling by nuclear magnetic resonance spectroscopy found that the serum levels of 2-hydroxybutyrate (2-HB), 3-hydoxybutyrate (3-HB), lactate, citrate, and tyrosine, were higher in patients who died within 3 months compared to those who were alive 3 months after onset of AHF, which was confirmed by univariable logistic regression analyses (p = 0.009, p = 0.005, p = 0.008, p<0.001, and p<0.001, respectively). These associations still remained significant for all tested metabolites except for lactate after adjusting for established prognostic parameters in HF. In conclusion, serum levels of 2-HB, 3-HB, tyrosine, and citrate measured at admission are associated with an increased 3-month mortality rate in AHF patients and might thus be of prognostic value in AHF.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 9, br. 1
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-019-42937-w
URN:NBNurn:nbn:hr:105:475691
Datum objave publikacije2019-05-01
URL dokumentahttp://doi.org/10.1038/s41598-019-42937-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:33:56