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Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Nature Communications, 10 (2019), 1; https://doi.org/10.1038/s41467-019-09775-w
Law, Philip J.; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia; Sud, Amit; Holroyd, Amy; Penegar, Steven; Theodoratou, Evropi; Vaughan-Shaw, Peter; Campbell, Harry; Zgaga, Lina; Hayward, Caroline; Campbell, Archie; Harris, Sarah; Deary, Ian J.; Starr, John; Gatcombe, Laura; Pinna, Maria; Briggs, Sarah; Martin, Lynn; Jaeger, Emma; Sharma-Oates, Archana; East, James; Leedham, Simon; Arnold, Roland; Johnstone, Elaine; Wang, Haitao; Kerr, David; Kerr, Rachel; Maughan, Tim; Kaplan, Richard; Al-Tassan, Nada; Palin, Kimmo; Hänninen, Ulrika A.; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Mecklin, Jukka-Pekka; Buchanan, Daniel D.; Win, Aung-Ko; Hopper, John; Jenkins, Mark E.; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steven; Duggan, David; Casey, Graham; Hoffmann, Per; Nöthen, Markus M.; Jöckel, Karl-Heinz; Easton, Douglas F.; Pharoah, Paul D. P.; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Pashayan, Nora; Harkin, Andrea; Allan, Karen; McQueen, John; Paul, James; Iveson, Timothy; Saunders, Mark; Butterbach, Katja; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Kirac, Iva; Matošević, Petar; Hofer, Philipp; Brezina, Stefanie; Gsur, Andrea; Cheadle, Jeremy P.; Aaltonen, Lauri A.; Tomlinson, Ian; Houlston, Richard S.; Dunlop, Malcolm G. Više autora...

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Law, P. J., Timofeeva, M., Fernandez Rozadilla, C., Broderick, P., Studd, J., Fernandez Tajes, J. ... Dunlop, M. G. (2019). Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature Communications, 10. (1). doi: 10.1038/s41467-019-09775-w

Law, Philip J., et al. "Association analyses identify 31 new risk loci for colorectal cancer susceptibility." Nature Communications, vol. 10, br. 1, 2019. https://doi.org/10.1038/s41467-019-09775-w

Law, Philip J., Maria Timofeeva, Ceres Fernandez Rozadilla, Peter Broderick, James Studd, Juan Fernandez Tajes, Susan Farrington, et al. "Association analyses identify 31 new risk loci for colorectal cancer susceptibility." Nature Communications 10, br. 1 (2019). https://doi.org/10.1038/s41467-019-09775-w

Law, P. J., et al. (2019) 'Association analyses identify 31 new risk loci for colorectal cancer susceptibility', Nature Communications, 10(1). doi: 10.1038/s41467-019-09775-w

Law PJ, Timofeeva M, Fernandez Rozadilla C, Broderick P, Studd J, Fernandez Tajes J, i sur.. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature Communications [Internet]. 14.05.2019. [pristupljeno 10.07.2024.];10(1). doi: 10.1038/s41467-019-09775-w

P. J. Law, et al., "Association analyses identify 31 new risk loci for colorectal cancer susceptibility", Nature Communications, vol. 10, br. 1, Svibanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:887802. [Citirano: 10.07.2024.]

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Naslov (engleski)Association analyses identify 31 new risk loci for colorectal cancer susceptibility
AutorPhilip J. Law
AutorMaria Timofeeva
AutorCeres Fernandez-Rozadilla
AutorPeter Broderick
AutorJames Studd
AutorJuan Fernandez-Tajes
AutorSusan Farrington
AutorVictoria Svinti
AutorClaire Palles
AutorGiulia Orlando
AutorAmit Sud
AutorAmy Holroyd
AutorSteven Penegar
AutorEvropi Theodoratou
AutorPeter Vaughan-Shaw
AutorHarry Campbell
AutorLina Zgaga
AutorCaroline Hayward
AutorArchie Campbell
AutorSarah Harris
AutorIan J. Deary
AutorJohn Starr
AutorLaura Gatcombe
AutorMaria Pinna
AutorSarah Briggs
AutorLynn Martin
AutorEmma Jaeger
AutorArchana Sharma-Oates
AutorJames East
AutorSimon Leedham
AutorRoland Arnold
AutorElaine Johnstone
AutorHaitao Wang
AutorDavid Kerr
AutorRachel Kerr
AutorTim Maughan
AutorRichard Kaplan
AutorNada Al-Tassan
AutorKimmo Palin
AutorUlrika A. Hänninen
AutorTatiana Cajuso
AutorTomas Tanskanen
AutorJohanna Kondelin
AutorEevi Kaasinen
AutorAntti-Pekka Sarin
AutorJohan G. Eriksson
AutorHarri Rissanen
AutorPaul Knekt
AutorEero Pukkala
AutorPekka Jousilahti
AutorVeikko Salomaa
AutorSamuli Ripatti
AutorAarno Palotie
AutorLaura Renkonen-Sinisalo
AutorAnna Lepistö
AutorJan Böhm
AutorJukka-Pekka Mecklin
AutorDaniel D. Buchanan
AutorAung-Ko Win
AutorJohn Hopper
AutorMark E. Jenkins
AutorNoralane M. Lindor
AutorPolly A. Newcomb
AutorSteven Gallinger
AutorDavid Duggan
AutorGraham Casey
AutorPer Hoffmann
AutorMarkus M. Nöthen
AutorKarl-Heinz Jöckel
AutorDouglas F. Easton
AutorPaul D. P. Pharoah
AutorJulian Peto
AutorFederico Canzian
AutorAnthony Swerdlow
AutorRosalind A. Eeles
AutorZsofia Kote-Jarai
AutorKenneth Muir
AutorNora Pashayan
AutorAndrea Harkin
AutorKaren Allan
AutorJohn McQueen
AutorJames Paul
AutorTimothy Iveson
AutorMark Saunders
AutorKatja Butterbach
AutorJenny Chang-Claude
AutorMichael Hoffmeister
AutorHermann Brenner
AutorIva Kirac
AutorPetar Matošević
AutorPhilipp Hofer
AutorStefanie Brezina
AutorAndrea Gsur
AutorJeremy P. Cheadle
AutorLauri A. Aaltonen
AutorIan Tomlinson
AutorRichard S. Houlston
AutorMalcolm G. Dunlop
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 10, br. 1
p-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-019-09775-w
URN:NBNurn:nbn:hr:105:887802
Datum objave publikacije2019-05-14
URL dokumentahttp://doi.org/10.1038/s41467-019-09775-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:35:14