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Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study
Oncotarget, 10 (2019), 62; 6713-6722. https://doi.org/10.18632/oncotarget.27333
Košec, Andro; Novak, Ruđer; Konjevoda, Paško; Trkulja, Vladimir; Bedeković, Vladimir; Grgurević, Lovorka

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Košec, A., Novak, R., Konjevoda, P., Trkulja, V., Bedeković, V. i Grgurević, L. (2019). Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study. Oncotarget, 10. (62), 6713-6722. doi: 10.18632/oncotarget.27333

Košec, Andro, et al. "Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study." Oncotarget, vol. 10, br. 62, 2019, str. 6713-6722. https://doi.org/10.18632/oncotarget.27333

Košec, Andro, Ruđer Novak, Paško Konjevoda, Vladimir Trkulja, Vladimir Bedeković i Lovorka Grgurević. "Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study." Oncotarget 10, br. 62 (2019): 6713-6722. https://doi.org/10.18632/oncotarget.27333

Košec, A., et al. (2019) 'Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study', Oncotarget, 10(62), str. 6713-6722. doi: 10.18632/oncotarget.27333

Košec A, Novak R, Konjevoda P, Trkulja V, Bedeković V, Grgurević L. Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study. Oncotarget [Internet]. 19.11.2019. [pristupljeno 08.11.2024.];10(62):6713-6722. doi: 10.18632/oncotarget.27333

A. Košec, R. Novak, P. Konjevoda, V. Trkulja, V. Bedeković i L. Grgurević, "Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study", Oncotarget, vol. 10, br. 62, str. 6713-6722, Studeni 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:118329. [Citirano: 08.11.2024.]

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Naslov (engleski)Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study
AutorAndro Košec
AutorRuđer Novak
AutorPaško Konjevoda
AutorVladimir Trkulja
AutorVladimir Bedeković
AutorLovorka Grgurević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Background: Breslow tumor thickness and mitotic rate are standardly used for risk stratification of patients with malignant melanoma. However, their prognostic value is relatively limited and a need for improved prognostication has been advocated. We aimed to screen the tumor tissue proteome in a search for potentially useful prognostic factors in early-stage cutaneous head and neck melanoma. ----- Methodology and findings: Proteomic profiles of archival formalin-fixed tissue samples of 31 patients (age 23-90 years) with early-stage head and neck cutaneous malignant melanoma (American Joint Committee on Cancer, AJCC, stage I/II) were determined and expression intensities were compared to those of melanocytic nevi, yielding ratios used in data analysis. Medical charts were retrospectively reviewed to determine time elapsed since diagnosis to disease-specific death or censoring. In a multivariate recursive partitioning analysis (as per AJCC guidelines), higher expression levels of heterogeneous nuclear ribonucleoprotein M (hnRNP M) [n = 18, HR = 1.94 vs. the entire cohort; HR = 5.95 (95%CI 2.43-14.5) for "high" vs. "low" (n = 13)] and of heat shock protein 90 alpha (HSP 90α) [n = 17, HR = 2.09 vs. the entire cohort; HR = 4.59 (95%CI 1.87-11.2) for "high" vs. "low" (n = 14)] were each independently strongly associated with higher mortality (accounting for clinical and standard pathohistological features). Higher Breslow thickness and mitotic rate were associated with higher mortality only when proteomic data were disregarded. ----- Conclusions and significance: Data suggest that tumor tissue expression of hnRNP M and/or of HSP 90α deserve further investigation and clinical validation as potential novel risk stratification aids in patients with stage I-II cutaneous head and neck malignant melanoma.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaOncotarget
Brojčani podacivol. 10, br. 62, str. 6713-6722
p-ISSN1949-2553
DOIhttps://doi.org/10.18632/oncotarget.27333
URN:NBNurn:nbn:hr:105:118329
Datum objave publikacije2019-11-19
URL dokumentahttps://doi.org/10.18632/oncotarget.27333
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:42:25