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Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease
Collegium Antropologicum, 31 (2007), 1; 179-183. urn:nbn:hr:105:539969
Bergman Marković, Biserka; Bergovec, Mijo; Reiner, Željko; Sertić, Jadranka; Vincelj, Josip; Marković, Maja

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Bergman Marković, B., Bergovec, M., Reiner, Ž., Sertić, J., Vincelj, J. i Marković, M. (2007). Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease. Collegium Antropologicum, 31. (1), 179-183. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:539969

Bergman Marković, Biserka, et al. "Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease." Collegium Antropologicum, vol. 31, br. 1, 2007, str. 179-183. https://urn.nsk.hr/urn:nbn:hr:105:539969

Bergman Marković, Biserka, Mijo Bergovec, Željko Reiner, Jadranka Sertić, Josip Vincelj i Maja Marković. "Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease." Collegium Antropologicum 31, br. 1 (2007): 179-183. https://urn.nsk.hr/urn:nbn:hr:105:539969

Bergman Marković, B., et al. (2007) 'Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease', Collegium Antropologicum, 31(1), str. 179-183. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:539969 (Datum pristupa: 15.04.2024.)

Bergman Marković B, Bergovec M, Reiner Ž, Sertić J, Vincelj J, Marković M. Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease. Collegium Antropologicum [Internet]. 03.2007. [pristupljeno 15.04.2024.];31(1):179-183. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:539969

B. Bergman Marković, M. Bergovec, Ž. Reiner, J. Sertić, J. Vincelj i M. Marković, "Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease", Collegium Antropologicum, vol. 31, br. 1, str. 179-183, Ožujak 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:539969. [Citirano: 15.04.2024.]

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Naslov (engleski)Deletion polymorphism of the angiotensin I-converting enzyme gene in elderly patients with coronary heart disease
AutorBiserka Bergman Marković
AutorMijo Bergovec
AutorŽeljko Reiner
AutorJadranka Sertić
AutorJosip Vincelj
AutorMaja Marković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Controversy exists as to whether the deletion/deletion (DD) genotype of angiotensin l-converting enzyme (ACE) gene polymorphism is associated with coronary heart disease (CHD). There are only a few studies dealing with this issue in the elderly, also with controversial results. The aim of this study was the assessment of correlation between genetic markers and the risk of CHD in the elderly. The results indicated DD genotype importance for CHD in the elderly as proven by discriminant analysis (chi2 = 25.77; df = 16; p = 0.0620). However, the use of univariate method demonstrated no correlation between DD genotype of ACE gene polymorphism and coronary artery disease. D allele of ACE gene was associated with higher activities of ACE plasma. A weak, but increased risk of MI is associated with high frequency of DD genotype in the elderly. Strong correlation between ACE polymorphism and ACE plasma activities was demonstrated.
Sažetak (hrvatski)
Povezanost delecijskog alela (DD genotip) angiotenzin konvertirajućeg enzima (ACE) sa koronarnom bolesti srca (KBS) je dvojbena. Malo je studija posvećeno tom problemu za stariju životnu dob, čiji rezultati su također dvojbeni. Cilj ovog rada je bio procijeniti povezanosti genetskih markera i rizika za KBS u starosti. Rezultati pokazuju da DD genotip ima prediktivnu vrijednost za KBS u starosti prikazano diskriminacijskom analizom (c2=25,77; df=16; P=0.0620). Međutim upotrebljavajući univarijatnu metodu povezanost DD genotipa i KBS nije dokazana. Vrijednost aktivnosti plazmatskog ACE u direktnoj je povezanosti s delecijskim polimorfizmom ACE gena. Zaključak: Povezanost DD genotipa i rizika za KBS u starijoj životnoj dobi također postoji. Prikazana je jaka povezanost ACE polimorfizma i vrijednosti aktivnosti plazmatskog ACE.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium Antropologicum
Brojčani podacivol. 31, br. 1, str. 179-183
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:539969
Datum objave publikacije2007-03
URL dokumentahttps://hrcak.srce.hr/27314
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 10:56:39