prikaz prve stranice dokumenta The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy
  Preuzmi
PDF 158.5 KB
Znanstveni rad - Izvorni znanstveni rad
The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy
Seizure, 17 (2008), 6; 524-530. https://doi.org/10.1016/j.seizure.2008.01.003
Bašić, Silvio; Hajnšek, Sanja; Božina, Nada; Filipčić, Igor; Sporiš, Davor; Mišlov, Damir; Posavec, Ana

Citirajte ovaj rad

Bašić, S., Hajnšek, S., Božina, N., Filipčić, I., Sporiš, D., Mišlov, D. i Posavec, A. (2008). The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy. Seizure, 17. (6), 524-530. doi: 10.1016/j.seizure.2008.01.003

Bašić, Silvio, et al. "The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy." Seizure, vol. 17, br. 6, 2008, str. 524-530. https://doi.org/10.1016/j.seizure.2008.01.003

Bašić, Silvio, Sanja Hajnšek, Nada Božina, Igor Filipčić, Davor Sporiš, Damir Mišlov i Ana Posavec. "The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy." Seizure 17, br. 6 (2008): 524-530. https://doi.org/10.1016/j.seizure.2008.01.003

Bašić, S., et al. (2008) 'The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy', Seizure, 17(6), str. 524-530. doi: 10.1016/j.seizure.2008.01.003

Bašić S, Hajnšek S, Božina N, Filipčić I, Sporiš D, Mišlov D, i sur.. The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy. Seizure [Internet]. 09.2008. [pristupljeno 07.11.2024.];17(6):524-530. doi: 10.1016/j.seizure.2008.01.003

S. Bašić, et al., "The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy", Seizure, vol. 17, br. 6, str. 524-530, Rujan 2008. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:292651. [Citirano: 07.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:292651
Prijavite se u repozitorij kako biste mogli spremiti objekt u svoju listu.
Podaci o radu
Naslov (engleski)The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-brain barrier in patients with generalized epilepsy
AutorSilvio Bašić
AutorSanja Hajnšek
AutorNada Božina
AutorIgor Filipčić
AutorDavor Sporiš
AutorDamir Mišlov
AutorAna Posavec
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: Epilepsy is refractory to medical treatment in about one-third of the patients. The exact pathological mechanism of epilepsy pharmacoresistance is still unclear, but a decreased antiepileptic drug (AED) uptake into the brain is suspected to play a role. P-glycoprotein (Pgp), a transmembrane transporter encoded by ABCB1 gene and located at the endothelial cells of the blood-brain barrier (BBB), has been associated with epilepsy pharmacoresistance. ----- OBJECTIVE: To analyze the effect of two ABCB1 gene polymorphisms, C3435T and G2677T/A, on phenobarbital (PB) concentrations in the cerebrospinal fluid (CSF) and serum (S) and to assess the relationship of ABCB1 polymorphisms to phenobarbital penetration across BBB in vivo and seizure frequency. ----- METHODS: CSF PB and S PB concentrations were measured in 60 patients with idiopathic primary generalized epilepsy receiving phenobarbital monotherapy. CSF/S PB concentration ratio was calculated as an index of phenobarbital penetration across BBB. The patients were genotyped for the ABCB1 gene C3435T and G2677T/A polymorphisms. Seizure frequency was recorded during the 6-month phenobarbital monotherapy. ----- RESULTS: Patients with different C3435T polymorphism had significantly different CSF PB concentrations and CSF/S PB concentration ratio. In comparison with CT heterozygotes and TT homozygotes, CC homozygotes had a significantly lower CSF PB concentration (p=0.006) and CSF/PB concentration ratio (p<0.001). G2677T/A polymorphism showed no such effect (p=0.466). CC genotype and low CSF/S PB concentration ratio correlated with increased seizure frequency. ----- CONCLUSIONS: C3435T polymorphism of ABCB1 gene was demonstrated in vivo to significantly influence the CSF/S PB concentration ratio and seizure frequency.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaSeizure
Brojčani podacivol. 17, br. 6, str. 524-530
p-ISSN1059-1311
DOIhttps://doi.org/10.1016/j.seizure.2008.01.003
URN:NBNurn:nbn:hr:105:292651
Datum objave publikacije2008-09
URL dokumentahttps://doi.org/10.1016/j.seizure.2008.01.003
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:08:36