prikaz prve stranice dokumenta Genome-wide association study of anthropometric traits in Korcula Island, Croatia
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Genome-wide association study of anthropometric traits in Korcula Island, Croatia
Croatian Medical Journal, 50 (2009), 1; 7-16. https://doi.org/10.3325/cmj.2009.50.7
Polašek, Ozren; Marušić, Ana; Rotim, Krešimir; Hayward, Caroline; Vitart, Veronique; Huffman, Jennifer; Campbell, Susan; Janković, Stipan; Boban, Mladen; Biloglav, Zrinka; Kolčić, Ivana; Krželj, Vjekoslav; Terzić, Janoš; Matec, Lana; Tometić, Gordan; Nonković, Dijana; Ninčević, Jasna; Pehlić, Marina; Žedelj, Jurica; Velagić, Vedran; Juričić, Danica; Kirac, Iva; Belak Kovačević, Sanja; Wright, Alan F.; Campbell, Harry; Rudan, Igor Više autora...

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Polašek, O., Marušić, A., Rotim, K., Hayward, C., Vitart, V., Huffman, J. ... Rudan, I. (2009). Genome-wide association study of anthropometric traits in Korcula Island, Croatia. Croatian Medical Journal, 50. (1), 7-16. doi: 10.3325/cmj.2009.50.7

Polašek, Ozren, et al. "Genome-wide association study of anthropometric traits in Korcula Island, Croatia." Croatian Medical Journal, vol. 50, br. 1, 2009, str. 7-16. https://doi.org/10.3325/cmj.2009.50.7

Polašek, Ozren, Ana Marušić, Krešimir Rotim, Caroline Hayward, Veronique Vitart, Jennifer Huffman, Susan Campbell, et al. "Genome-wide association study of anthropometric traits in Korcula Island, Croatia." Croatian Medical Journal 50, br. 1 (2009): 7-16. https://doi.org/10.3325/cmj.2009.50.7

Polašek, O., et al. (2009) 'Genome-wide association study of anthropometric traits in Korcula Island, Croatia', Croatian Medical Journal, 50(1), str. 7-16. doi: 10.3325/cmj.2009.50.7

Polašek O, Marušić A, Rotim K, Hayward C, Vitart V, Huffman J, i sur.. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. Croatian Medical Journal [Internet]. 02.2009. [pristupljeno 22.12.2024.];50(1):7-16. doi: 10.3325/cmj.2009.50.7

O. Polašek, et al., "Genome-wide association study of anthropometric traits in Korcula Island, Croatia", Croatian Medical Journal, vol. 50, br. 1, str. 7-16, Veljača 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:861112. [Citirano: 22.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:861112
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Naslov (engleski)Genome-wide association study of anthropometric traits in Korcula Island, Croatia
AutorOzren Polašek
AutorAna Marušić
AutorKrešimir Rotim
AutorCaroline Hayward
AutorVeronique Vitart
AutorJennifer Huffman
AutorSusan Campbell
AutorStipan Janković
AutorMladen Boban
AutorZrinka Biloglav
AutorIvana Kolčić
AutorVjekoslav Krželj
AutorJanoš Terzić
AutorLana Matec
AutorGordan Tometić
AutorDijana Nonković
AutorJasna Ninčević
AutorMarina Pehlić
AutorJurica Žedelj
AutorVedran Velagić
AutorDanica Juričić
AutorIva Kirac
AutorSanja Belak Kovačević
AutorAlan F. Wright
AutorHarry Campbell
AutorIgor Rudan
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Sažetak (engleski)
AIM: To identify genetic variants underlying six anthropometric traits: body height, body weight, body mass index, brachial circumference, waist circumference, and hip circumference, using a genome-wide association study. ----- METHODS: The study was carried out in the isolated population of the island of Korcula, Croatia, with 898 adult examinees who participated in the larger DNA-based genetic epidemiological study in 2007. Anthropometric measurements followed standard internationally accepted procedures. Examinees were genotyped using HumanHap 370CNV chip by Illumina, with a genome-wide scan containing 316730 single nucleotide polymorphisms (SNP). ----- RESULTS: A total of 11 SNPs were associated with the investigated traits at the level of P<10(-5), with one SNP (rs7792939 in gene zinc finger protein 498, ZNF498) associated with body weight, hip circumference, and brachial circumference (P=3.59-5.73 x 10(-6)), and another one (rs157350 in gene delta-sarcoglycan, SGCD) with both brachial and hip circumference (P=3.70-6.08 x 10(-6). Variants in CRIM1, a gene regulating delivery of bone morphogenetic proteins to the cell surface, and ITGA1, involved in the regulation of mesenchymal stem cell proliferation and cartilage production, were also associated with brachial circumference (P=7.82 and 9.68 x 10(-6), respectively) and represent interesting functional candidates. Other associations involved those between genes SEZ6L2 and MAX and waist circumference, XTP6 and brachial circumference, and AMPA1/GRIA1 and height. ----- CONCLUSION: Although the study was underpowered for the reported associations to reach formal threshold of genome-wide significance under the assumption of independent multiple testing, the consistency of association between the 2 variants and a set of anthropometric traits makes CRIM1 and ITGA1 highly interesting for further replication and functional follow-up. Increased linkage disequilibrium between the used markers in an isolated population makes the formal significance threshold overly stringent, and changed allele frequencies in isolate population may contribute to identifying variants that would not be easily identified in large outbred populations.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 50, br. 1, str. 7-16
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2009.50.7
URN:NBNurn:nbn:hr:105:861112
Datum objave publikacije2009-02
URL dokumentahttp://www.cmj.hr/2009/50/1/19260139.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 11:14:13