Efficacy and safety of budesonide/formeterol combination therapy in asthma patients

Znanstveni rad - Izvorni znanstveni rad

• Naslov (hrvatski): Učinkovitost i sigurnost kombinacije budezonida i formoterola u bolesnika sa astmom
• Autor: Marko Jakopović
• Autor: Fadila Pavičić
• Autor: Gzim Redžepi
• Autor: Sanja Pleština
• Autor: Mateja Janković
• Autor: Zrinka Franić
• Autor: Mirko Šamija
• Autor: Miroslav Samaržija
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti

Sažetak (engleski)

Budesonide/formoterol as single inhaler was developed for treating asthma patients who are not adequately controlled on glucocorticoides alone. The aim of this study was to evaluate efficacy, safety and patient/physician satisfaction of budesonide/formoterol therapy.Total of 268 asthma patients (120 men, mean age 38.8 +/- 37.2 years, and 148 women, mean age 42.2 +/- 32 years) were included in the study. All patients received budesonide/formoterol bid (640 mcg of budesonide and 18 mcg of formoterol daily) during run-in period for three weeks. Patients were followed during 14 weeks at 5 visits. At each visit lung function (FEV1 and PEF) was measured,presence of side affects was recorded and questionnaire was given to patients and physicians to estimate the level of satisfaction with budesonide/formoterol therapy (1 very unsatisfied to 5 very satisfied). Significant improvement was noticed in FEV1, from 76.25% of predicted value to 86.94% (p < 0.01); and in PEF from 380.84 L/min to 442.29 L/min (p < 0.01) in all patients. At the end of the study patients' satisfaction with budesonide/formeterol therapy was significantly improved comparing with satisfaction with previously taken therapy, in average grade, from 2.94 to 4.56 (p < 0.01), and similar results were noticed with physicians' satisfaction, from 2.60 to 4.41 (p < 0.01). Budesonide/formoterol in single inhaler, significantly improved lung function in patients with asthma.

Sažetak (hrvatski)

Kombinacija budezonida i formoterola u jednom inhalatoru koristi se u bolesnika koji nemaju dobru kontrolu astme uz inhalacijske kortikosteroide. Cilj ovog rada je procijeniti učinkovitost i sigurnost fiksne kombinacije budezonida i formoterola te procijeniti zadovoljstvo bolesnika i liječnika navedenom terapijom. U studiju je uključeno ukupno 120 ispitanika. Svi bolesnici su koristili budezonid/formoterol dva puta na dan u ukupnoj dozi 640 mcg budezonida i 18 mcg formoterola kroz tri tjedna. Bolesnici su praćeni tijekom 14 tjedana u 5 posjeta. Na svakoj posjeti mjerena je plućna funkcija, bilježeno prisustvo nuspojava, te su bolesnici i liječnici ispunjavali upitnik o zadovoljstvu liječenjem. Tijekom praćenja nađeno je značajno poboljšanje u plućnoj funkciju (FEV1 i PEF). Također, na kraju studije značajno veće zadovoljstvo liječenjem pokazano je i medu ispitanicima i među liječnicima. U konačnici, budezonid i formoterol u jednom inhalatoru značajno poboljšava plućnu funkciju, te zadovoljstvo liječenjem u bolesnika s astmom.

• Ključne riječi (engleski): Administration, Inhalation; Adolescent; Adult; Aged; Asthma/drug therapy; Bronchodilator Agents/administration & dosage; Bronchodilator Agents/adverse effects; Budesonide/administration & dosage; Budesonide/adverse effects; Child; Drug Combinations; Ethanolamines/administration & dosage; Ethanolamines/adverse effects; Female; Humans; Male; Middle Aged; Patient Satisfaction; Young Adult
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Izvorni znanstveni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Collegium Antropologicum
• Brojčani podaci: vol. 33, br. 2, str. 587-591
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:891222
• Datum objave publikacije: 2009-06
• URL dokumenta: https://hrcak.srce.hr/40561
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-03-28 11:20:05