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Central origin of the antinociceptive action of botulinum toxin type A
Pharmacology, Biochemistry, and Behavior, 94 (2009), 2; 234-238. https://doi.org/10.1016/j.pbb.2009.08.012
Bach-Rojecky, Lidija; Lacković, Zdravko

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Bach Rojecky, L. i Lacković, Z. (2009). Central origin of the antinociceptive action of botulinum toxin type A. Pharmacology, Biochemistry, and Behavior, 94. (2), 234-238. doi: 10.1016/j.pbb.2009.08.012

Bach Rojecky, Lidija i Zdravko Lacković. "Central origin of the antinociceptive action of botulinum toxin type A." Pharmacology, Biochemistry, and Behavior, vol. 94, br. 2, 2009, str. 234-238. https://doi.org/10.1016/j.pbb.2009.08.012

Bach Rojecky, Lidija i Zdravko Lacković. "Central origin of the antinociceptive action of botulinum toxin type A." Pharmacology, Biochemistry, and Behavior 94, br. 2 (2009): 234-238. https://doi.org/10.1016/j.pbb.2009.08.012

Bach Rojecky, L. i Lacković, Z. (2009) 'Central origin of the antinociceptive action of botulinum toxin type A', Pharmacology, Biochemistry, and Behavior, 94(2), str. 234-238. doi: 10.1016/j.pbb.2009.08.012

Bach Rojecky L, Lacković Z. Central origin of the antinociceptive action of botulinum toxin type A. Pharmacology, Biochemistry, and Behavior [Internet]. 12.2009. [pristupljeno 04.05.2024.];94(2):234-238. doi: 10.1016/j.pbb.2009.08.012

L. Bach Rojecky i Z. Lacković, "Central origin of the antinociceptive action of botulinum toxin type A", Pharmacology, Biochemistry, and Behavior, vol. 94, br. 2, str. 234-238, Prosinac 2009. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:488242. [Citirano: 04.05.2024.]

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Podaci o radu
Naslov (engleski)Central origin of the antinociceptive action of botulinum toxin type A
AutorLidija Bach-Rojecky
AutorZdravko Lacković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Here we provide behavioural evidence for an axonal transport and the central origin of the antinociceptive effect of botulinum toxin type A (BTX-A). In rats we investigated the effectiveness of BTX-A on "mirror pain" induced by unilateral repeated intramuscular acidic saline injections (pH 4.0). Since experimental evidence suggest that bilateral pain induced by acidic saline is of central origin, peripheral application of BTX-A should have no effect on this type of pain. However, here we demonstrated that the unilateral subcutaneous BTX-A (5U/kg) application diminished pain on the ipsilateral, and on the contralateral side too. When injected into the proximal part of a distally cut sciatic nerve, BTX-A still reduced pain on the contralateral side. Colchicine, an axonal transport blocker, when injected into the ipsilateral sciatic nerve, prevented the effect of the peripheral BTX-A injection on both sides. Additionally, when BTX-A (1U/kg) was applied intrathecally in the lumbar cerebrospinal fluid, the bilateral hyperalgesia was also reduced. The results demonstrate the necessity of retrograde axonal transport and involvement of the central nervous system for the antinociceptive activity of BTX-A.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPharmacology, Biochemistry, and Behavior
Brojčani podacivol. 94, br. 2, str. 234-238
p-ISSN0091-3057
DOIhttps://doi.org/10.1016/j.pbb.2009.08.012
URN:NBNurn:nbn:hr:105:488242
Datum objave publikacije2009-12
URL dokumentahttps://doi.org/10.1016/j.pbb.2009.08.012
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 11:25:55