prikaz prve stranice dokumenta Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats
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Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats
Acta Biochimica Polonica, 57 (2010), 3; 321-326. urn:nbn:hr:105:363656
Macan, Marija; Vrkić, Nada; Lucić Vrdoljak, Ana; Radić, Božica; Bradamante, Vlasta

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Macan, M., Vrkić, N., Lucić Vrdoljak, A., Radić, B. i Bradamante, V. (2010). Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats. Acta Biochimica Polonica, 57. (3), 321-326. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:105:363656

Macan, Marija, et al. "Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats." Acta Biochimica Polonica, vol. 57, br. 3, 2010, str. 321-326. https://urn.nsk.hr/urn:nbn:hr:105:363656

Macan, Marija, Nada Vrkić, Ana Lucić Vrdoljak, Božica Radić i Vlasta Bradamante. "Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats." Acta Biochimica Polonica 57, br. 3 (2010): 321-326. https://urn.nsk.hr/urn:nbn:hr:105:363656

Macan, M., et al. (2010) 'Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats', Acta Biochimica Polonica, 57(3), str. 321-326. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:105:363656 (Datum pristupa: 10.04.2024.)

Macan M, Vrkić N, Lucić Vrdoljak A, Radić B, Bradamante V. Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats. Acta Biochimica Polonica [Internet]. 11.06.2010. [pristupljeno 10.04.2024.];57(3):321-326. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:363656

M. Macan, N. Vrkić, A. Lucić Vrdoljak, B. Radić i V. Bradamante, "Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats", Acta Biochimica Polonica, vol. 57, br. 3, str. 321-326, Lipanj 2010. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:363656. [Citirano: 10.04.2024.]

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Naslov (engleski)Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats
AutorMarija Macan
AutorNada Vrkić
AutorAna Lucić Vrdoljak
AutorBožica Radić
AutorVlasta Bradamante
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
We investigated the influence of high sucrose diet (HSD) after 3 or 5 weeks of administration on paraoxonase 1 (PON1) activity in plasma of normolipidemic rats and the relationship between serum PON1 activity, triacylglycerides (TGs), HDL and total cholesterol vs. the control group of rats fed normal, control diet (CD). Because the data about the influence of gemfibrozil (GEM) on PON1 activity are controversial, we also investigated its effects (administration in the 4th and 5th week in rats on HSD and CD) on plasma PON1 activity and lipid levels in normolipidemic rats, and in rats with hypertriglyceridemia caused by HSD. Our results obtained in rats on HSD show a significant increase of plasma TGs levels by 47% (P<0.05) after 5 weeks of treatment, and PON1 activity by 32% and 23% (P<0.05) after 3 and 5 weeks, but without change in lipid levels vs. rats on CD. In the rats on CD and HSD, GEM caused a significant decrease of PON1 activity by 44% and 33%, while a significant decrease of TGs level by 38% (P<0.05) was measured only in rats on CD. The effects of GEM on total cholesterol, HDL and LDL in both groups of rats were typical for its action on lipoprotein metabolism. Because GEM in the rat liver stimulates proliferation of peroxisomes, β oxidation, and production of H2O2, it is possible that the oxidative stress induced by GEM damages hepatocytes and lowers the synthesis of PON1.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Biochimica Polonica
Brojčani podacivol. 57, br. 3, str. 321-326
p-ISSN0001-527X
URN:NBNurn:nbn:hr:105:363656
Datum objave publikacije2010-06-11
URL dokumentahttp://www.actabp.pl/pdf/3_2010/321.pdf
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 11:50:27