prikaz prve stranice dokumenta Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
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Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
JCI Insight, 8 (2023), 11; e166978. https://doi.org/10.1172/jci.insight.166978
Fabris, Federico; Varani, Stefano; Tonellato, Marika; Matak, Ivica; Šoštarić, Petra; Meglić, Patrik; Caleo, Matteo; Megighian, Aram; Rossetto, Ornella; Montecucco, Cesare; Pirazzini, Marco

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Fabris, F., Varani, S., Tonellato, M., Matak, I., Šoštarić, P., Meglić, P. ... Pirazzini, M. (2023). Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus. JCI Insight, 8. (11). doi: 10.1172/jci.insight.166978

Fabris, Federico, et al. "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus." JCI Insight, vol. 8, br. 11, 2023. https://doi.org/10.1172/jci.insight.166978

Fabris, Federico, Stefano Varani, Marika Tonellato, Ivica Matak, Petra Šoštarić, Patrik Meglić, Matteo Caleo, et al. "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus." JCI Insight 8, br. 11 (2023). https://doi.org/10.1172/jci.insight.166978

Fabris, F., et al. (2023) 'Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus', JCI Insight, 8(11). doi: 10.1172/jci.insight.166978

Fabris F, Varani S, Tonellato M, Matak I, Šoštarić P, Meglić P, i sur.. Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus. JCI Insight [Internet]. 09.05.2023. [pristupljeno 02.05.2024.];8(11). doi: 10.1172/jci.insight.166978

F. Fabris, et al., "Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus", JCI Insight, vol. 8, br. 11, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:695304. [Citirano: 02.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:695304
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Naslov (engleski)Facial neuromuscular junctions and brainstem nuclei are the target of tetanus neurotoxin in cephalic tetanus
AutorFederico Fabris
AutorStefano Varani
AutorMarika Tonellato
AutorIvica Matak
AutorPetra Šoštarić
AutorPatrik Meglić
AutorMatteo Caleo
AutorAram Megighian
AutorOrnella Rossetto
AutorCesare Montecucco
AutorMarco Pirazzini
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Cephalic tetanus (CT) is a severe form of tetanus that follows head wounds and the intoxication of cranial nerves by tetanus neurotoxin (TeNT). Hallmarks of CT are cerebral palsy, which anticipates the spastic paralysis of tetanus, and rapid evolution of cardiorespiratory deficit even without generalized tetanus. How TeNT causes this unexpected flaccid paralysis, and how the canonical spasticity then rapidly evolves into cardiorespiratory defects, remain unresolved aspects of CT pathophysiology. Using electrophysiology and immunohistochemistry, we demonstrate that TeNT cleaves its substrate vesicle-associated membrane protein within facial neuromuscular junctions and causes a botulism-like paralysis overshadowing tetanus spasticity. Meanwhile, TeNT spreads among brainstem neuronal nuclei and, as shown by an assay measuring the ventilation ability of CT mice, harms essential functions like respiration. A partial axotomy of the facial nerve revealed a potentially new ability of TeNT to undergo intra-brainstem diffusion, which allows the toxin to spread to brainstem nuclei devoid of direct peripheral efferents. This mechanism is likely to be involved in the transition from local to generalized tetanus. Overall, the present findings suggest that patients with idiopathic facial nerve palsy should be immediately considered for CT and treated with antisera to block the potential progression to a life-threatening form of tetanus.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJCI Insight
Brojčani podacivol. 8, br. 11, e166978
e-ISSN2379-3708
DOIhttps://doi.org/10.1172/jci.insight.166978
URN:NBNurn:nbn:hr:105:695304
Datum objave publikacije2023-05-09
ProjektŠifra: UIP-2019-04-8277
Naziv (hrvatski): Motorički učinci klostridijskih neurotoksina u središnjem živčanom sustavu
Naziv (engleski): Motor effects of clostridial neurotoxins in central nervous system
Kratica: MEFCLO
Voditelj: Ivica Matak
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
URL dokumentahttps://insight.jci.org/articles/view/166978
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-04-04 11:21:33