prikaz prve stranice dokumenta Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease
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Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease
BMC Medicine, 15 (2017), 1; 27. https://doi.org/10.1186/s12916-017-0799-3
Malojčić, Branko; Giannakopoulos, Panteleimon; Sorond, Farzaneh A.; Azevedo, Elsa; Diomedi, Marina; Pretnar Oblak, Janja; Carraro, Nicola; Boban, Marina; Olah, Laszlo; Schreiber, Stephan J.; Pavlović, Aleksandra; Garami, Zsolt; Bornstein, Nantan M.; Rosengarten, Bernhard

Citirajte ovaj rad

Malojčić, B., Giannakopoulos, P., Sorond, F. A., Azevedo, E., Diomedi, M., Pretnar Oblak, J. ... Rosengarten, B. (2017). Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease. BMC Medicine, 15. (1), 27. doi: 10.1186/s12916-017-0799-3

Malojčić, Branko, et al. "Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease." BMC Medicine, vol. 15, br. 1, 2017, str. 27. https://doi.org/10.1186/s12916-017-0799-3

Malojčić, Branko, Panteleimon Giannakopoulos, Farzaneh A. Sorond, Elsa Azevedo, Marina Diomedi, Janja Pretnar Oblak, Nicola Carraro, et al. "Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease." BMC Medicine 15, br. 1 (2017): 27. https://doi.org/10.1186/s12916-017-0799-3

Malojčić, B., et al. (2017) 'Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease', BMC Medicine, 15(1), str. 27. doi: 10.1186/s12916-017-0799-3

Malojčić B, Giannakopoulos P, Sorond FA, Azevedo E, Diomedi M, Pretnar Oblak J, i sur.. Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease. BMC Medicine [Internet]. 09.02.2017. [pristupljeno 13.11.2024.];15(1):27. doi: 10.1186/s12916-017-0799-3

B. Malojčić, et al., "Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease", BMC Medicine, vol. 15, br. 1, str. 27, Veljača 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:225515. [Citirano: 13.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:225515
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Naslov (engleski)Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease
AutorBranko Malojčić
AutorPanteleimon Giannakopoulos
AutorFarzaneh A. Sorond
AutorElsa Azevedo
AutorMarina Diomedi
AutorJanja Pretnar Oblak
AutorNicola Carraro
AutorMarina Boban
AutorLaszlo Olah
AutorStephan J. Schreiber
AutorAleksandra Pavlović
AutorZsolt Garami
AutorNantan M. Bornstein
AutorBernhard Rosengarten
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
BACKGROUND: The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely available, safe and relatively low cost tools and analyses recent work highlighting their potential utility as biomarkers for differentiating subtypes of cognitive impairment and dementia, tracking disease progression and evaluating response to treatment in various neurocognitive disorders. ----- METHODS: At the 9th International Congress on Vascular Dementia (Ljubljana, Slovenia, October 2015) a writing group of experts was formed to review the evidence on the utility of US and arterial spin labelling (ASL) as neurophysiological markers of normal ageing, vascular cognitive impairment (VCI) and Alzheimer's disease (AD). Original articles, systematic literature reviews, guidelines and expert opinions published until September 2016 were critically analysed to summarise existing evidence, indicate gaps in current knowledge and, when appropriate, suggest standards of use for the most widely used US and ASL applications. ----- RESULTS: Cerebral hypoperfusion has been linked to cognitive decline either as a risk or an aggravating factor. Hypoperfusion as a consequence of microangiopathy, macroangiopathy or cardiac dysfunction can promote or accelerate neurodegeneration, blood-brain barrier disruption and neuroinflammation. US can evaluate the cerebrovascular tree for pathological structure and functional changes contributing to cerebral hypoperfusion. Microvascular pathology and hypoperfusion at the level of capillaries and small arterioles can also be assessed by ASL, an MRI signal. Despite increasing evidence supporting the utility of these methods in detection of microvascular pathology, cerebral hypoperfusion, neurovascular unit dysfunction and, most importantly, disease progression, incomplete standardisation and missing validated cut-off values limit their use in daily routine. ----- CONCLUSIONS: US and ASL are promising tools with excellent temporal resolution, which will have a significant impact on our understanding of the vascular contributions to VCI and AD and may also be relevant for assessing future prevention and therapeutic strategies for these conditions. Our work provides recommendations regarding the use of non-invasive imaging techniques to investigate the functional consequences of vascular burden in dementia.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBMC Medicine
Brojčani podacivol. 15, br. 1, str. 27
p-ISSN1741-7015
DOIhttps://doi.org/10.1186/s12916-017-0799-3
URN:NBNurn:nbn:hr:105:225515
Datum objave publikacije2017-02-09
URL dokumentahttps://doi.org/10.1186/s12916-017-0799-3
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-04-09 05:48:26