prikaz prve stranice dokumenta Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
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Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
Scientific Reports, 7 (2017), 1; 7273. https://doi.org/10.1038/s41598-017-07839-9
Herrera-Molina, Rodrigo; Mlinac-Jerković, Kristina; Ilić, Katarina; Stöber, Franziska; Vemula, Sampath Kumar; Sandoval, Mauricio; Jovanov Milošević, Nataša; Šimić, Goran; Smalla, Karl-Heinz; Goldschmidt, Jürgen; Kalanj Bognar, Svjetlana; Montag, Dirk

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Herrera Molina, R., Mlinac Jerković, K., Ilić, K., Stöber, F., Vemula, S. K., Sandoval, M. ... Montag, D. (2017). Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration. Scientific Reports, 7. (1), 7273. doi: 10.1038/s41598-017-07839-9

Herrera Molina, Rodrigo, et al. "Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration." Scientific Reports, vol. 7, br. 1, 2017, str. 7273. https://doi.org/10.1038/s41598-017-07839-9

Herrera Molina, Rodrigo, Kristina Mlinac Jerković, Katarina Ilić, Franziska Stöber, Sampath Kumar Vemula, Mauricio Sandoval, Nataša Jovanov Milošević, et al. "Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration." Scientific Reports 7, br. 1 (2017): 7273. https://doi.org/10.1038/s41598-017-07839-9

Herrera Molina, R., et al. (2017) 'Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration', Scientific Reports, 7(1), str. 7273. doi: 10.1038/s41598-017-07839-9

Herrera Molina R, Mlinac Jerković K, Ilić K, Stöber F, Vemula SK, Sandoval M, i sur.. Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration. Scientific Reports [Internet]. 04.08.2017. [pristupljeno 02.05.2024.];7(1):7273. doi: 10.1038/s41598-017-07839-9

R. Herrera Molina, et al., "Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration", Scientific Reports, vol. 7, br. 1, str. 7273, Kolovoz 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:063386. [Citirano: 02.05.2024.]

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Naslov (engleski)Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration
AutorRodrigo Herrera-Molina
AutorKristina Mlinac-Jerković
AutorKatarina Ilić
AutorFranziska Stöber
AutorSampath Kumar Vemula
AutorMauricio Sandoval
AutorNataša Jovanov Milošević
AutorGoran Šimić
AutorKarl-Heinz Smalla
AutorJürgen Goldschmidt
AutorSvjetlana Kalanj Bognar
AutorDirk Montag
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The cell adhesion molecule neuroplastin (Np) is a novel candidate to influence human intelligence. Np-deficient mice display complex cognitive deficits and reduced levels of Plasma Membrane Ca2+ ATPases (PMCAs), an essential regulator of the intracellular Ca2+ concentration ([iCa2+]) and neuronal activity. We show abundant expression and conserved cellular and molecular features of Np in glutamatergic neurons in human hippocampal-cortical pathways as characterized for the rodent brain. In Nptn lox/loxEmx1Cre mice, glutamatergic neuron-selective Np ablation resulted in behavioral deficits indicating hippocampal, striatal, and sensorimotor dysfunction paralleled by highly altered activities in hippocampal CA1 area, sensorimotor cortex layers I-III/IV, and the striatal sensorimotor domain detected by single-photon emission computed tomography. Altered hippocampal and cortical activities correlated with reduction of distinct PMCA paralogs in Nptn lox/loxEmx1Cre mice and increased [iCa2+] in cultured mutant neurons. Human and rodent Np enhanced the post-transcriptional expression of and co-localized with PMCA paralogs in the plasma membrane of transfected cells. Our results indicate Np as essential for PMCA expression in glutamatergic neurons allowing proper [iCa2+] regulation and normal circuit activity. Neuron-type-specific Np ablation empowers the investigation of circuit-coded learning and memory and identification of causal mechanisms leading to cognitive deterioration.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScientific Reports
Brojčani podacivol. 7, br. 1, str. 7273
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-017-07839-9
URN:NBNurn:nbn:hr:105:063386
Datum objave publikacije2017-08-04
URL dokumentahttps://doi.org/10.1038/s41598-017-07839-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-04-09 05:48:57