Optimization of cardiovascular risk factor management in patients with BCR::ABL1 negative chronic myeloproliferative neoplasms, current knowledge, and perspectives

Znanstveni rad - Pregledni rad

• Autor: Ivan Krečak
• Autor: Srdan Verstovsek
• Autor: Marko Lucijanić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina

Sažetak (engleski)

The exact prognostic role of cardiovascular (CV) risk factors in patients with BCR::ABL1 negative chronic myeloproliferative neoplasms (MPNs) remains unknown as it is often masked by other MPN-related features that bear strong prognostic impact on thrombotic risk. Therefore, current MPN treatment is not primarily guided by presence of CV risk factors. Treatment of CV risk factors in MPN patients usually mirrors that from the general population, despite the fact that CV risk factors in MPNs have their own specificities. Moreover, the optimal target levels for different metabolic deflections in MPNs (i.e., low-density lipoprotein, serum uric acid, or glycated hemoglobin levels) have not been defined. In the current review, we separately discuss the most important aspects of every individual CV risk factor (arterial hypertension, hyperlipidemia, chronic kidney disease, smoking, diabetes mellitus, hyperuricemia, and obesity and cachexia) in MPNs, summarize recent advances in the field, and propose future directions and research areas which may be needed to appropriately manage CV risk factors in MPNs.

• Ključne riječi (engleski): Bone Marrow Neoplasms / genetics; Bone Marrow Neoplasms / therapy; Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / etiology; Fusion Proteins, bcr-abl; Humans; Myeloproliferative Disorders / genetics; Myeloproliferative Disorders / therapy; Risk Factors; Uric Acid / blood; Uric Acid / chemistry
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Završna verzija rukopisa prihvaćena za objavljivanje (postprint)
• Naslov časopisa: Annals of Hematology
• Brojčani podaci: vol. 103, br. 5, str. 1513-1523
• p-ISSN: 0939-5555
• e-ISSN: 1432-0584
• DOI: https://doi.org/10.1007/s00277-023-05426-9
• URN:NBN: urn:nbn:hr:105:613579
• Datum objave publikacije: 2023-09-04
• URL dokumenta: https://link.springer.com/10.1007/s00277-023-05426-9
• Vrsta resursa: Tekst
• Prava pristupa: Pristup ograničen embargom; Datum isteka embarga: 2025-06-01
• Datum i vrijeme pohrane: 2024-05-06 08:16:50