prikaz prve stranice dokumenta Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
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Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
Frontiers in Endocrinology, 14 (2023); 1181064. https://doi.org/10.3389/fendo.2023.1181064
Ivić, Vedrana; Zjalić, Milorad; Blažetić, Senka; Fenrich, Matija; Labak, Irena; Scitovski, Rudolf; Szűcs, Kálmán Ferenc; Ducza, Eszter; Tábi, Tamás; Bagamery, Fruzsina; Szökő, Éva; Vuković, Rosemary; Rončević, Alen; Mandić, Dario; Debeljak, Željko; Berecki, Monika; Balog, Marta; Seres-Bokor, Adrienn; Sztojkov-Ivanov, Anita; Hajagos-Tóth, Judit; Gajović, Srećko; Imširović, Alen; Bakula, Marina; Mahiiovych, Solomiia; Gaspar, Robert; Vari, Sandor G.; Heffer, Marija Više autora...

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Ivić, V., Zjalić, M., Blažetić, S., Fenrich, M., Labak, I., Scitovski, R. ... Heffer, M. (2023). Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment. Frontiers in Endocrinology, 14.. doi: 10.3389/fendo.2023.1181064

Ivić, Vedrana, et al. "Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment." Frontiers in Endocrinology, vol. 14, 2023. https://doi.org/10.3389/fendo.2023.1181064

Ivić, Vedrana, Milorad Zjalić, Senka Blažetić, Matija Fenrich, Irena Labak, Rudolf Scitovski, Kálmán Ferenc Szűcs, et al. "Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment." Frontiers in Endocrinology 14 (2023). https://doi.org/10.3389/fendo.2023.1181064

Ivić, V., et al. (2023) 'Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment', Frontiers in Endocrinology, 14. doi: 10.3389/fendo.2023.1181064

Ivić V, Zjalić M, Blažetić S, Fenrich M, Labak I, Scitovski R, i sur.. Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment. Frontiers in Endocrinology [Internet]. 20.10.2023. [pristupljeno 24.05.2024.];14. doi: 10.3389/fendo.2023.1181064

V. Ivić, et al., "Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment", Frontiers in Endocrinology, vol. 14, Listopad 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:662491. [Citirano: 24.05.2024.]

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Naslov (engleski)Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment
AutorVedrana Ivić
AutorMilorad Zjalić
AutorSenka Blažetić
AutorMatija Fenrich
AutorIrena Labak
AutorRudolf Scitovski
AutorKálmán Ferenc Szűcs
AutorEszter Ducza
AutorTamás Tábi
AutorFruzsina Bagamery
AutorÉva Szökő
AutorRosemary Vuković
AutorAlen Rončević
AutorDario Mandić
AutorŽeljko Debeljak
AutorMonika Berecki
AutorMarta Balog
AutorAdrienn Seres-Bokor
AutorAnita Sztojkov-Ivanov
AutorJudit Hajagos-Tóth
AutorSrećko Gajović
AutorAlen Imširović
AutorMarina Bakula
AutorSolomiia Mahiiovych
AutorRobert Gaspar
AutorSandor G. Vari
AutorMarija Heffer
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA HISTOLOGIJU I EMBRIOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Citologija, histologija i embriologija
Sažetak (engleski)
Aim/introduction: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old. Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sex-specific effects, but neither prevented the onset of prediabetes nor diabetes. Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Endocrinology
Brojčani podacivol. 14, 1181064
e-ISSN1664-2392
DOIhttps://doi.org/10.3389/fendo.2023.1181064
URN:NBNurn:nbn:hr:105:662491
Datum objave publikacije2023-10-20
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fendo.2023.1181064/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-06 08:33:30