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Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals
Antibodies, 12 (2023), 4; 61. https://doi.org/10.3390/antib12040061
Vilibić-Čavlek, Tatjana; Stevanović, Vladimir; Kovač, Snježana; Borko, Ema; Bogdanić, Maja; Miletić, Gorana; Hruskar, Željka; Ferenc, Thomas; Ćorić, Ivona; Vujica Ferenc, Mateja; Milasincic, Ljiljana; Antolašić, Ljiljana; Barbić, Ljubo

Citirajte ovaj rad

Vilibić Čavlek, T., Stevanović, V., Kovač, S., Borko, E., Bogdanić, M., Miletić, G. ... Barbić, Lj. (2023). Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals. Antibodies, 12. (4). doi: 10.3390/antib12040061

Vilibić Čavlek, Tatjana, et al. "Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals." Antibodies, vol. 12, br. 4, 2023. https://doi.org/10.3390/antib12040061

Vilibić Čavlek, Tatjana, Vladimir Stevanović, Snježana Kovač, Ema Borko, Maja Bogdanić, Gorana Miletić, Željka Hruskar, et al. "Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals." Antibodies 12, br. 4 (2023). https://doi.org/10.3390/antib12040061

Vilibić Čavlek, T., et al. (2023) 'Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals', Antibodies, 12(4). doi: 10.3390/antib12040061

Vilibić Čavlek T, Stevanović V, Kovač S, Borko E, Bogdanić M, Miletić G, i sur.. Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals. Antibodies [Internet]. 25.09.2023. [pristupljeno 20.10.2024.];12(4). doi: 10.3390/antib12040061

T. Vilibić Čavlek, et al., "Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals", Antibodies, vol. 12, br. 4, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:122245. [Citirano: 20.10.2024.]

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Podaci o radu
Naslov (engleski)Neutralizing Activity of SARS-CoV-2 Antibodies in Patients with COVID-19 and Vaccinated Individuals
AutorTatjana Vilibić-Čavlek
AutorVladimir Stevanović
AutorSnježana Kovač
AutorEma Borko
AutorMaja Bogdanić
AutorGorana Miletić
AutorŽeljka Hruskar
AutorThomas Ferenc
AutorIvona Ćorić
AutorMateja Vujica Ferenc
AutorLjiljana Milasincic
AutorLjiljana Antolašić
AutorLjubo Barbić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Background: Serological diagnosis of COVID-19 is complex due to the emergence of different SARS-CoV-2 variants. Methods: 164 serum samples from (I) patients who recovered from COVID-19 (n = 62) as well as (II) vaccinated individuals (n = 52) and (III) vaccinated individuals who were infected with different SARS-CoV-2 variants after vaccination (n = 50) were included. All samples were tested using EIA (binding antibodies) and a virus neutralization test (VNT) using the Wuhan strain (NT antibodies). Group III was further tested with a VNT using the Alpha/Delta/Omicron strains. Results: The highest antibody index (AI) was observed in vaccinated individuals infected with COVID-19 (median AI = 50, IQR = 27-71) and the lowest in vaccinated individuals (median AI = 19, IQR = 8-48). Similarly, NT antibody titer was highest in vaccinated individuals infected with COVID-19 (median 128; IQR = 32-256) compared to vaccinated individuals (median 32, IQR = 4-128) and patients with COVID-19 (median 32, IQR = 8-64). The correlation between AI and NT titer was strongly positive in vaccinated individuals and moderately positive in patients with COVID-19. No significant correlation was observed in vaccinated individuals infected with COVID-19. In patients infected with Alpha and Delta, the lowest VNT positivity rate was for the Omicron variant (85.0%/83.3%). Patients infected with the Alpha variant showed the lowest NT titer for the Omicron variant (median titer 32) compared to the Wuhan/Delta variants (64/128). Patients infected with the Delta variant had the lowest NT titer to the Omicron variant (median 32), compared to the Wuhan/Alpha variants (64/128). Patients infected with the Omicron variant showed similar titers to the Delta/Wuhan variants (128) and higher to the Alpha variant (256). Conclusions: The cross-immunity to SARS-CoV-2 is lowest for the Omicron variant compared to the Alpha/Delta variants.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaAntibodies
Brojčani podacivol. 12, br. 4, 61
e-ISSN2073-4468
DOIhttps://doi.org/10.3390/antib12040061
URN:NBNurn:nbn:hr:105:122245
Datum objave publikacije2023-09-25
URL dokumentahttps://www.mdpi.com/2073-4468/12/4/61
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-17 07:33:29