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Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults
Biomedicines, 11 (2023), 9; 2561. https://doi.org/10.3390/biomedicines11092561
Bulum, Tomislav; Vučić Lovrenčić, Marijana; Knežević Ćuća, Jadranka; Tomić, Martina; Vučković-Rebrina, Sandra; Duvnjak, Lea

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Bulum, T., Vučić Lovrenčić, M., Knežević Ćuća, J., Tomić, M., Vučković Rebrina, S. i Duvnjak, L. (2023). Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults. Biomedicines, 11. (9). doi: 10.3390/biomedicines11092561

Bulum, Tomislav, et al. "Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults." Biomedicines, vol. 11, br. 9, 2023. https://doi.org/10.3390/biomedicines11092561

Bulum, Tomislav, Marijana Vučić Lovrenčić, Jadranka Knežević Ćuća, Martina Tomić, Sandra Vučković Rebrina i Lea Duvnjak. "Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults." Biomedicines 11, br. 9 (2023). https://doi.org/10.3390/biomedicines11092561

Bulum, T., et al. (2023) 'Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults', Biomedicines, 11(9). doi: 10.3390/biomedicines11092561

Bulum T, Vučić Lovrenčić M, Knežević Ćuća J, Tomić M, Vučković Rebrina S, Duvnjak L. Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults. Biomedicines [Internet]. 18.09.2023. [pristupljeno 10.07.2024.];11(9). doi: 10.3390/biomedicines11092561

T. Bulum, M. Vučić Lovrenčić, J. Knežević Ćuća, M. Tomić, S. Vučković Rebrina i L. Duvnjak, "Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults", Biomedicines, vol. 11, br. 9, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:958001. [Citirano: 10.07.2024.]

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Podaci o radu
Naslov (engleski)Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults
AutorTomislav Bulum
AutorMarijana Vučić Lovrenčić
AutorJadranka Knežević Ćuća
AutorMartina Tomić
AutorSandra Vučković-Rebrina
AutorLea Duvnjak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Aims: Our study aimed to investigate the relationship between three autoantibodies and their combination with anthropometric and metabolic components and microvascular complications in patients with latent autoimmune diabetes in adults (LADA). Methods: Our study included 189 LADA patients divided into four subgroups according to the autoantibodies present: glutamic acid decarboxylase autoantibodies (GADA) only; zinc transporter-8 autoantibodies (ZnT8A)+GADA; insulinoma-associated-2 autoantibodies (IA-2)+GADA; and ZnT8+IA-2+GADA. Results: Compared to GADA positivity only, patients with ZnT8+GADA positivity and ZnT8+IA-2+GADA positivity had a shorter diabetes duration and lower body mass index (BMI); patients with ZnT8+GADA positivity were younger and showed an increase in glomerular filtration rate, while those with ZnT8+IA-2+GADA positivity had lower C-peptide and lower insulin resistance measured with HOMA2-IR. In a multiple regression analysis, ZnT8 positivity was associated with lower BMI (p = 0.0024), female sex (p = 0.0005), and shorter duration of disease (p = 0.0034), while IA-2 positivity was associated with lower C-peptide levels (p = 0.0034) and shorter diabetes duration (p = 0.02). No association between antibody positivity and microvascular complications of diabetes, including retinopathy, neuropathy, and microalbuminuria, as well as with variables of glucose control and β-cell function were found. Conclusion: The results of our study suggest that ZnT8 and IA-2 autoantibodies are present in a significant number of LADA patients and associated with clinical and metabolic characteristics resembling classic type 1 diabetes. Due to increased LADA prevalence, earlier identification of patients requiring frequent monitoring with the earlier intensification of insulin therapy might be of special clinical interest.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 11, br. 9, 2561
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11092561
URN:NBNurn:nbn:hr:105:958001
Datum objave publikacije2023-09-18
URL dokumentahttps://www.mdpi.com/2227-9059/11/9/2561
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-21 09:11:52