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Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients
Biomolecules, 13 (2023), 9; 1323. https://doi.org/10.3390/biom13091323
Klobučar, Iva; Vidović, Luka; Arih, Ilona; Lechleitner, Margarete; Pregartner, Gudrun; Berghold, Andrea; Habisch, Hansjörg; Madl, Tobias; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Vidović, L., Arih, I., Lechleitner, M., Pregartner, G., Berghold, A. ... Degoricija, V. (2023). Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients. Biomolecules, 13. (9). doi: 10.3390/biom13091323

Klobučar, Iva, et al. "Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients." Biomolecules, vol. 13, br. 9, 2023. https://doi.org/10.3390/biom13091323

Klobučar, Iva, Luka Vidović, Ilona Arih, Margarete Lechleitner, Gudrun Pregartner, Andrea Berghold, Hansjörg Habisch, Tobias Madl, Saša Frank i Vesna Degoricija. "Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients." Biomolecules 13, br. 9 (2023). https://doi.org/10.3390/biom13091323

Klobučar, I., et al. (2023) 'Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients', Biomolecules, 13(9). doi: 10.3390/biom13091323

Klobučar I, Vidović L, Arih I, Lechleitner M, Pregartner G, Berghold A, i sur.. Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients. Biomolecules [Internet]. 29.08.2023. [pristupljeno 23.06.2024.];13(9). doi: 10.3390/biom13091323

I. Klobučar, et al., "Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients", Biomolecules, vol. 13, br. 9, Kolovoz 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:305544. [Citirano: 23.06.2024.]

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Podaci o radu
Naslov (engleski)Low Valine Serum Levels Predict Increased 1-Year Mortality in Acute Heart Failure Patients
AutorIva Klobučar
AutorLuka Vidović
AutorIlona Arih
AutorMargarete Lechleitner
AutorGudrun Pregartner
AutorAndrea Berghold
AutorHansjörg Habisch
AutorTobias Madl
AutorSaša Frank
AutorVesna Degoricija
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Considering the relationship between disease severity and the extent of metabolic derangement in heart failure, we hypothesized that the serum levels of metabolites may have prognostic value for 1-year mortality in acute heart failure (AHF). The AHF study was a prospective, observational study enrolling consecutive patients hospitalized due to AHF. Metabolites were measured in serum collected at admission using NMR spectroscopy. Out of 315 AHF patients, 118 (37.5%) died within 1 year after hospitalization for AHF. The serum levels of 8 out of 49 identified metabolites were significantly different between patients who were alive and those who died within 1 year after hospitalization for AHF. Of these, only valine was significantly associated with 1-year mortality (hazard ratio 0.73 per 1 standard deviation increase, 95% confidence interval: 0.59–0.90, p = 0.003) in the multivariable Cox regression analyses. Kaplan–Maier analysis showed significantly higher survival rates in AHF patients with valine levels above the median (>279.2 µmol/L) compared to those with valine levels ≤ 279.2 µmol/L. In a receiver operating characteristics curve analysis, valine was able to discriminate between the two groups with an area under the curve of 0.65 (95% CI 0.59–0.72). We conclude that valine serum levels might be of prognostic value in AHF.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomolecules
Brojčani podacivol. 13, br. 9, 1323
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom13091323
URN:NBNurn:nbn:hr:105:305544
Datum objave publikacije2023-08-29
URL dokumentahttps://www.mdpi.com/2218-273X/13/9/1323
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-21 10:31:59