prikaz prve stranice dokumenta Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
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Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Nature Communications, 14 (2023), 1; 6025. https://doi.org/10.1038/s41467-023-41730-8
Salamon, Iva; Park, Yongkyu; Miškić, Terezija; Kopić, Janja; Matteson, Paul; Page, Nicholas F.; Roque, Alfonso; McAuliffe, Geoffrey W.; Favate, John; Garcia-Forn, Marta; Shah, Premal; Judaš, Miloš; Millonig, James H.; Kostović, Ivica; De Rubeis, Silvia; Hart, Ronald P.; Krsnik, Željka; Rasin, Mladen-Roko Više autora...

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Salamon, I., Park, Y., Miškić, T., Kopić, J., Matteson, P., Page, N. F. ... Rasin, M. R. (2023). Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nature Communications, 14. (1). doi: 10.1038/s41467-023-41730-8

Salamon, Iva, et al. "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex." Nature Communications, vol. 14, br. 1, 2023. https://doi.org/10.1038/s41467-023-41730-8

Salamon, Iva, Yongkyu Park, Terezija Miškić, Janja Kopić, Paul Matteson, Nicholas F. Page, Alfonso Roque, et al. "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex." Nature Communications 14, br. 1 (2023). https://doi.org/10.1038/s41467-023-41730-8

Salamon, I., et al. (2023) 'Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex', Nature Communications, 14(1). doi: 10.1038/s41467-023-41730-8

Salamon I, Park Y, Miškić T, Kopić J, Matteson P, Page NF, i sur.. Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nature Communications [Internet]. 27.09.2023. [pristupljeno 10.09.2024.];14(1). doi: 10.1038/s41467-023-41730-8

I. Salamon, et al., "Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex", Nature Communications, vol. 14, br. 1, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:613610. [Citirano: 10.09.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:613610
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Naslov (engleski)Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
AutorIva Salamon
AutorYongkyu Park
AutorTerezija Miškić
AutorJanja Kopić
AutorPaul Matteson
AutorNicholas F. Page
AutorAlfonso Roque
AutorGeoffrey W. McAuliffe
AutorJohn Favate
AutorMarta Garcia-Forn
AutorPremal Shah
AutorMiloš Judaš
AutorJames H. Millonig
AutorIvica Kostović
AutorSilvia De Rubeis
AutorRonald P. Hart
AutorŽeljka Krsnik
AutorMladen-Roko Rasin
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
Abnormalities in neocortical and synaptic development are linked to neurodevelopmental disorders. However, the molecular and cellular mechanisms governing initial synapse formation in the prenatal neocortex remain poorly understood. Using polysome profiling coupled with snRNAseq on human cortical samples at various fetal phases, we identify human mRNAs, including those encoding synaptic proteins, with finely controlled translation in distinct cell populations of developing frontal neocortices. Examination of murine and human neocortex reveals that the RNA binding protein and translational regulator, CELF4, is expressed in compartments enriched in initial synaptogenesis: the marginal zone and the subplate. We also find that Celf4/CELF4-target mRNAs are encoded by risk genes for adverse neurodevelopmental outcomes translating into synaptic proteins. Surprisingly, deleting Celf4 in the forebrain disrupts the balance of subplate synapses in a sex-specific fashion. This highlights the significance of RNA binding proteins and mRNA translation in evolutionarily advanced synaptic development, potentially contributing to sex differences.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 14, br. 1, 6025
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-41730-8
URN:NBNurn:nbn:hr:105:613610
Datum objave publikacije2023-09-27
URL dokumentahttps://www.nature.com/articles/s41467-023-41730-8
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-21 10:36:46