Genitalne HPV infekcije u trudnoći

Scientific paper - Review paper

• Title (english): Genital HPV infections in pregnancy
• Author: Karla Kovačević
• Author: Mihael Skerlev
• Author: Hrvoje Vrčić
• Author: Petra Kovačević
• Author: Suzana Ljubojević Hadžavdić
• Author's institution: University of Zagreb; School of Medicine; (Department of Dermatology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract (croatian)

Humani papiloma virusi (HPV) su mali, epitelotropni DNK virusi. Dosadašnji podatci ukazuju na postojanje
više od dvjesto genotipova virusa, od kojih oko četrdeset uzrokuje infekcije genitalnog područja. S obzirom
na onkogeni potencijal, razlikujemo genotipove visokog (HPV 16, HPV 18, itd.) i genotipove niskog rizika (HPV 6,
HPV 11, itd.). Genitalni HPV najčešće se prenosi kontaktom s inficiranom kožom ili sluznicom. Ostali načini prijenosa
uključuju neizravni kontakt s kontaminiranim predmetima te autoinokulaciju. HPV uzrokuje različite
promjene
genitalne regije poput kondiloma, intraepitelnih neoplazija i invazivnih karcinoma cerviksa, vulve,
penisa ili anusa. Također, HPV može prouzročiti lezije u područjima izvan genitalne regije kao što su usna šupljina,
ždrijelo, grlo i jednjak. Ne postoji suglasnost vezana uz prevalenciju HPV-a tijekom trudnoće, pa ona varira u
različitim zemljama između 5,5% i 65%. Vertikalni prijenos HPV-a označava mogućnost prijenosa HPV-a s majke
na dijete tijekom trudnoće. Do perikonceptualnog prijenosa HPV DNA dolazi u vrijeme fertilizacije, dok se antenatalni
prijenos događa isključivo za vrijeme trudnoće. No, većina HPV infekcija novorođenčadi nastaje perinatalnim
prijenosom tijekom porođaja. Incidencija anogenitalnih kondiloma u trudnoći iznosi između 11,6% i 28,2%. Oni
predstavljaju rizik od kontaminacije novorođenčeta HPV-om tijekom porođaja. Porastom učestalosti pojavljivanja
anogenitalnih kondiloma u odraslih uočen je i usporedni porast incidencije anogenitalnih kondiloma u djece. HPV
u djece može uzrokovati i rekurentnu respiratornu papilomatozu koju karakterizira nastajanje multiplih papiloma
glasnica. Rijetko dolazi do totalne opstrukcije dišnog puta ili progresije u karcinom.

Abstract (english)

Human papilloma viruses (HPV) are small, epitheliotropic DNA viruses. More than two hundred
different HPV genotypes are known today, of which around forty types cause genital infection. According to their
oncogenic potential the viruses are divided in high-risk HPV genotypes (HPV 16, HPV 18, etc.) and low-risk genotypes
(HPV 6, HPV 11, etc.). Genital HPV is most frequently transmitted through contact with infected skin or
mucous membranes. Other routes of transmission are via contaminated fomites and autoinoculation. HPV causes
genital warts, intraepithelial neoplasia and invasive carcinoma of cervix, vulva, penis or anus.Also, HPV can cause
lesions in non-genital areas such as oral cavity, pharynx, throat and esophagus. There is no consensus regarding
the prevalence of HPV during pregnancy, so it varies in different countries between 5.5 % and 65 %. The otential
route of HPV transmission from mother to child during pregnancy is known as vertical transmission. Periconceptual
transmission of HPV DNA occurs during fertilization, while prenatal transmission happens only during pregnancy.
Most infant HPV infections occur via perinatal transmission during delivery. The incidence of anogenital
warts in pregnancy is between 11.6 % and 28.2 %. Anogenital warts increase the risk of infant HPV contamination
during delivery. As the incidence of anogenital warts increased in adults, increased incidence was also
reported in children. HPV can cause recurrent respiratory papillomatosis in children, a disease characterized with
laryngeal papillomatosis. In rare cases, total obstruction of airway or progression in carcinoma can occur.

• Keywords (croatian): INFEKCIJE HUMANIM PAPILOMA VIRUSOM – patologija, prijenos, virologija; KOMPLIKACIJE INFEKCIJA U TRUDNOĆI – patologija, virologija; INFEKCIJE GENITALNOG TRAKTA – patologija, virologija; SPOLNO PRENOSIVE BOLESTI – patologija, prijenos, virologija; VERTIKALNI PRIJENOS INFEKCIJE; INFEKCIJE ONKOGENIM VIRUSOM – prijenos, virologija; ŠILJASTI KONDILOMI – liječenje, virologija; INFEKCIJE DIŠNOG SUSTAVA – dijagnoza, liječenje, virologija; NOVOROĐENČE
• Keywords (english): PAPILLOMAVIRUS INFECTIONS – pathology, transmission, virology; PREGNANCY COMPLICATIONS, INFECTIOUS – pathology, virology; REPRODUCTIVE TRACT INFECTIONS – pathology, virology; SEXUALLY TRANSMITTED DISEASES – pathology, transmission, virology; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; TUMOR VIRUS INFECTIONS – transmission, virology; CONDYLOMATA ACUMINATA – therapy, virology; RESPIRATORY TRACT INFECTIONS – diagnosis, therapy, virology; INFANT; NEWBORN
• Language: croatian
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 142, no. 7-8, pp. 244-250
• p-ISSN: 0024-3477
• e-ISSN: 1849-2177
• DOI: https://doi.org/10.26800/LV-142-7-8-40
• URN:NBN: urn:nbn:hr:105:437693
• Publication: 2020
• Document URL: https://hrcak.srce.hr/index.php?show=clanak&id_clanak_jezik=353590
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-11-26 08:36:15