Sarkopenija i kronične bolesti jetre

master's thesis

• Title (english): Sarcopenia and chronic liver diseases
• Author: Paula Božić
• Mentor: Anna Mrzljak (mentor)
• Committee member: Rajko Ostojić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Anna Mrzljak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Sarkopenija je sindrom progresivnoga i generaliziranoga gubitka skeletne mišićne mase, redukcije mišićne snage i posljedičnoga funkcionalnog poremećaja. Stanje je koje zbog negativnog utjecaja na lokomotorni, ali i na niz drugih organskih sustava, otežava svakodnevni život i narušava zdravlje pojedinca. Sarkopeniju prvi put spominje Rosenberg 1989. godine i do danas je opisano nekoliko definicija i kategorija. Prevalencija primarne sarkopenije u populaciji osoba starijih od 60 godina penje se do 50%. U kronično bolesnih pacijenata ta je brojka još i viša te prevalencija sekundarne sarkopenije u pacijenata s kroničnim bolestima jetre doseže vrijednost od 70%. Bez obzira na etiologiju, visoka prevalencija i neliječena sarkopenija uzrok su povećanja invaliditeta, morbiditeta i mortaliteta. U svrhu ranog otkrivanja sarkopenije razvijaju se i testiraju brojne dijagnostičke metode, od kojih za sad najbolje rezultate pokazuju kompjutorizirana tomografija i magnetna rezonancija. Patofiziologija sarkopenije i kroničnih bolesti jetre je kompleksna, mehanizmi se isprepliću te uzajamno pogoršavaju stanje i otežavaju liječenje. Jedinstveni lijek za sarkopeniju još ne postoji, ali razni farmakološki i nefarmakološki pristupi pokazuju pozitivne rezultate. Cilj je ovoga preglednog rada sažeti poznate spoznaje o sarkopeniji, upozoriti na utjecaj sarkopenije na pacijente s kroničnim bolestima jetre te istaknuti važnost njezina ranog dijagnosticiranja i liječenja.

Abstract (english)

Sarcopenia is a syndrome of progressive and generalized loss of skeletal muscle mass, reduction in muscle strength and consequential functional impairment. It is a condition which due to negative influence on locomotor and other organ systems complicate everyday life and impairs the health of individuals. Sarcopenia was first mentioned by Rosenberg in 1989 and several definitions and categories have been described to date. The prevalence of primary sarcopenia in the population of persons over 60 years of age is up to 50%. In chronically ill patients, this figure increases even more and the prevalence of secondary sarcopenia in patients with chronic liver diseases reaches 70%. Regardless of etiology, high prevalence and untreated sarcopenia are the cause of increased disability, morbidity and mortality. For the purpose of early detection of sarcopenia, numerous diagnostic methods are developed and tested, of which so far, the best results show computed tomography and magnetic resonance imaging. Pathophysiology of sarcopenia and chronic liver diseases is complex, and mechanisms intertwine, making the both conditions worse and difficult to treat. The unique cure for sarcopenia does not exist for now but various pharmacological and non-pharmacological approaches show positive results. The aim of this review is to summaries known findings on sarcopenia, to warn on the impact of sarcopenia on patients with chronic liver disease, and to highlight the importance of its early diagnosis and treatment.

• Keywords: dijagnostika; kronične bolesti jetre; nutritivni status; sarkopenija
• Keywords (english): chronic liver disease; diagnostic; nutritional status; sarcopenia
• Language: croatian
• URN:NBN: urn:nbn:hr:105:403425
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-09-02 07:57:09