prikaz prve stranice dokumenta Serum chitotriosidase: a circulating biomarker in polycythemia vera
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Scientific paper - Original scientific paper
Serum chitotriosidase: a circulating biomarker in polycythemia vera
Hematology, 23 (2018), 10; 793-802. https://doi.org/10.1080/10245332.2018.1498157
Krečak, Ivan; Gverić-Krečak, Velka; Rončević, Pavle; Bašić-Kinda, Sandra; Gulin, Josipa; Lapić, Ivana; Fumić, Ksenija; Ilić, Ivana; Horvat, Ivana; Zadro, Renata; Holik, Hrvoje; Coha, Božena; Peran, Nena; Aurer, Igor; Duraković, Nadira More authors...

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Krečak, I., Gverić Krečak, V., Rončević, P., Bašić Kinda, S., Gulin, J., Lapić, I. ... Duraković, N. (2018). Serum chitotriosidase: a circulating biomarker in polycythemia vera. Hematology, 23. (10), 793-802. doi: 10.1080/10245332.2018.1498157

Krečak, Ivan, et al. "Serum chitotriosidase: a circulating biomarker in polycythemia vera." Hematology, vol. 23, no. 10, 2018, pp. 793-802. https://doi.org/10.1080/10245332.2018.1498157

Krečak, Ivan, Velka Gverić Krečak, Pavle Rončević, Sandra Bašić Kinda, Josipa Gulin, Ivana Lapić, Ksenija Fumić, et al. "Serum chitotriosidase: a circulating biomarker in polycythemia vera." Hematology 23, no. 10 (2018): 793-802. https://doi.org/10.1080/10245332.2018.1498157

Krečak, I., et al. (2018) 'Serum chitotriosidase: a circulating biomarker in polycythemia vera', Hematology, 23(10), pp. 793-802. doi: 10.1080/10245332.2018.1498157

Krečak I, Gverić Krečak V, Rončević P, Bašić Kinda S, Gulin J, Lapić I, and sur.. Serum chitotriosidase: a circulating biomarker in polycythemia vera. Hematology [Internet]. 2018 December [cited 2024 December 26];23(10):793-802. doi: 10.1080/10245332.2018.1498157

I. Krečak, et al., "Serum chitotriosidase: a circulating biomarker in polycythemia vera", Hematology, vol. 23, no. 10, pp. 793-802, December 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:812109. [Accessed: 26 December 2024]

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Metadata
Title (english)Serum chitotriosidase: a circulating biomarker in polycythemia vera
AuthorIvan Krečak
AuthorVelka Gverić-Krečak
AuthorPavle Rončević
AuthorSandra Bašić-Kinda
AuthorJosipa Gulin
AuthorIvana Lapić
AuthorKsenija Fumić
AuthorIvana Ilić
AuthorIvana Horvat
AuthorRenata Zadro
AuthorHrvoje Holik
AuthorBožena Coha
AuthorNena Peran
AuthorIgor Aurer
AuthorNadira Duraković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objectives: Serum chitotriosidase activity (CHIT1) is a biomarker of macrophage activation with an important role in inflammation-induced tissue remodeling and fibrosis. Macrophages have been described to play a crucial role in regulating pathological erythropoiesis in polycythemia vera (PV). The aim of this study was to evaluate CHIT1 in patients diagnosed with Philadelphia-negative myeloproliferative neoplasms (MPNs). ----- Methods: Using fluorometric assay, we measured CHIT1 in 28 PV, 27 essential thrombocythemia (ET), 17 primary myelofibrosis (PMF), 19 patients with secondary myelofibrosis and in 25 healthy controls. ----- Results: CHIT1 was significantly higher in PV (p < .001) and post-PV myelofibrosis (MF) transformation (post-PV MF) (p = .020), but not in ET (p = .080), post-ET MF transformation (p = .086), and PMF patients (p = .287), when compared to healthy controls. CHIT1 in PV was positively correlated with hemoglobin (p = .026), hematocrit (p = .012), absolute basophil count (p = .030) and the presence of reticulin fibrosis in the bone marrow (p = .023). ----- Discussion: A positive correlation between CHIT1 and these distinct laboratory PV features might imply macrophages closely related to clonal erythropoiesis as cells of CHIT1 origin. In addition, a positive association between CHIT1 and reticulin fibrosis might indicate its potential role in PV progression. ----- Conclusion: CHIT1 might be considered as a circulating biomarker in PV. Additional studies are needed to clarify the role of CHIT1 in promoting disease progression and bone marrow fibrosis in PV.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleHematology
Numberingvol. 23, no. 10, pp. 793-802
p-ISSN1607-8454
DOIhttps://doi.org/10.1080/10245332.2018.1498157
URN:NBNurn:nbn:hr:105:812109
Publication2018-12
Document URLhttps://doi.org/10.1080/10245332.2018.1498157
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:41:18