prikaz prve stranice dokumenta Serum chitotriosidase: a circulating biomarker in polycythemia vera
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Serum chitotriosidase: a circulating biomarker in polycythemia vera
Hematology, 23 (2018), 10; 793-802. https://doi.org/10.1080/10245332.2018.1498157
Krečak, Ivan; Gverić-Krečak, Velka; Rončević, Pavle; Bašić-Kinda, Sandra; Gulin, Josipa; Lapić, Ivana; Fumić, Ksenija; Ilić, Ivana; Horvat, Ivana; Zadro, Renata; Holik, Hrvoje; Coha, Božena; Peran, Nena; Aurer, Igor; Duraković, Nadira Više autora...

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Krečak, I., Gverić Krečak, V., Rončević, P., Bašić Kinda, S., Gulin, J., Lapić, I. ... Duraković, N. (2018). Serum chitotriosidase: a circulating biomarker in polycythemia vera. Hematology, 23. (10), 793-802. doi: 10.1080/10245332.2018.1498157

Krečak, Ivan, et al. "Serum chitotriosidase: a circulating biomarker in polycythemia vera." Hematology, vol. 23, br. 10, 2018, str. 793-802. https://doi.org/10.1080/10245332.2018.1498157

Krečak, Ivan, Velka Gverić Krečak, Pavle Rončević, Sandra Bašić Kinda, Josipa Gulin, Ivana Lapić, Ksenija Fumić, et al. "Serum chitotriosidase: a circulating biomarker in polycythemia vera." Hematology 23, br. 10 (2018): 793-802. https://doi.org/10.1080/10245332.2018.1498157

Krečak, I., et al. (2018) 'Serum chitotriosidase: a circulating biomarker in polycythemia vera', Hematology, 23(10), str. 793-802. doi: 10.1080/10245332.2018.1498157

Krečak I, Gverić Krečak V, Rončević P, Bašić Kinda S, Gulin J, Lapić I, i sur.. Serum chitotriosidase: a circulating biomarker in polycythemia vera. Hematology [Internet]. 12.2018. [pristupljeno 28.11.2024.];23(10):793-802. doi: 10.1080/10245332.2018.1498157

I. Krečak, et al., "Serum chitotriosidase: a circulating biomarker in polycythemia vera", Hematology, vol. 23, br. 10, str. 793-802, Prosinac 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:812109. [Citirano: 28.11.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:812109
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Naslov (engleski)Serum chitotriosidase: a circulating biomarker in polycythemia vera
AutorIvan Krečak
AutorVelka Gverić-Krečak
AutorPavle Rončević
AutorSandra Bašić-Kinda
AutorJosipa Gulin
AutorIvana Lapić
AutorKsenija Fumić
AutorIvana Ilić
AutorIvana Horvat
AutorRenata Zadro
AutorHrvoje Holik
AutorBožena Coha
AutorNena Peran
AutorIgor Aurer
AutorNadira Duraković
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
Objectives: Serum chitotriosidase activity (CHIT1) is a biomarker of macrophage activation with an important role in inflammation-induced tissue remodeling and fibrosis. Macrophages have been described to play a crucial role in regulating pathological erythropoiesis in polycythemia vera (PV). The aim of this study was to evaluate CHIT1 in patients diagnosed with Philadelphia-negative myeloproliferative neoplasms (MPNs). ----- Methods: Using fluorometric assay, we measured CHIT1 in 28 PV, 27 essential thrombocythemia (ET), 17 primary myelofibrosis (PMF), 19 patients with secondary myelofibrosis and in 25 healthy controls. ----- Results: CHIT1 was significantly higher in PV (p < .001) and post-PV myelofibrosis (MF) transformation (post-PV MF) (p = .020), but not in ET (p = .080), post-ET MF transformation (p = .086), and PMF patients (p = .287), when compared to healthy controls. CHIT1 in PV was positively correlated with hemoglobin (p = .026), hematocrit (p = .012), absolute basophil count (p = .030) and the presence of reticulin fibrosis in the bone marrow (p = .023). ----- Discussion: A positive correlation between CHIT1 and these distinct laboratory PV features might imply macrophages closely related to clonal erythropoiesis as cells of CHIT1 origin. In addition, a positive association between CHIT1 and reticulin fibrosis might indicate its potential role in PV progression. ----- Conclusion: CHIT1 might be considered as a circulating biomarker in PV. Additional studies are needed to clarify the role of CHIT1 in promoting disease progression and bone marrow fibrosis in PV.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaHematology
Brojčani podacivol. 23, br. 10, str. 793-802
p-ISSN1607-8454
DOIhttps://doi.org/10.1080/10245332.2018.1498157
URN:NBNurn:nbn:hr:105:812109
Datum objave publikacije2018-12
URL dokumentahttps://doi.org/10.1080/10245332.2018.1498157
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 10:41:18