prikaz prve stranice dokumenta Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
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Scientific paper - Original scientific paper
Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
International Journal of Molecular Sciences, 25 (2024), 9; 5050. https://doi.org/10.3390/ijms25095050
Klobučar, Iva; Habisch, Hansjörg; Klobučar, Lucija; Trbušić, Matias; Pregartner, Gudrun; Berghold, Andrea; Kostner, Gerhard M.; Scharnagl, Hubert; Madl, Tobias; Frank, Saša; Degoricija, Vesna

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Klobučar, I., Habisch, H., Klobučar, L., Trbušić, M., Pregartner, G., Berghold, A. ... Degoricija, V. (2024). Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome. International Journal of Molecular Sciences, 25. (9). doi: 10.3390/ijms25095050

Klobučar, Iva, et al. "Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome." International Journal of Molecular Sciences, vol. 25, no. 9, 2024. https://doi.org/10.3390/ijms25095050

Klobučar, Iva, Hansjörg Habisch, Lucija Klobučar, Matias Trbušić, Gudrun Pregartner, Andrea Berghold, Gerhard M. Kostner, et al. "Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome." International Journal of Molecular Sciences 25, no. 9 (2024). https://doi.org/10.3390/ijms25095050

Klobučar, I., et al. (2024) 'Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome', International Journal of Molecular Sciences, 25(9). doi: 10.3390/ijms25095050

Klobučar I, Habisch H, Klobučar L, Trbušić M, Pregartner G, Berghold A, and sur.. Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome. International Journal of Molecular Sciences [Internet]. 2024 May 06 [cited 2025 February 21];25(9). doi: 10.3390/ijms25095050

I. Klobučar, et al., "Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome", International Journal of Molecular Sciences, vol. 25, no. 9, May 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:205726. [Accessed: 21 February 2025]

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Metadata
Title (english)Serum Levels of Adiponectin Are Strongly Associated with Lipoprotein Subclasses in Healthy Volunteers but Not in Patients with Metabolic Syndrome
AuthorIva Klobučar
AuthorHansjörg Habisch
AuthorLucija Klobučar
AuthorMatias Trbušić
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorGerhard M. Kostner
AuthorHubert Scharnagl
AuthorTobias Madl
AuthorSaša Frank
AuthorVesna Degoricija
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Metabolic syndrome (MS) is a widespread disease in developed countries, accompanied, among others, by decreased adiponectin serum levels and perturbed lipoprotein metabolism. The associations between the serum levels of adiponectin and lipoproteins have been extensively studied in the past under healthy conditions, yet it remains unexplored whether the observed associations also exist in patients with MS. Therefore, in the present study, we analyzed the serum levels of lipoprotein subclasses using nuclear magnetic resonance spectroscopy and examined their associations with the serum levels of adiponectin in patients with MS in comparison with healthy volunteers (HVs). In the HVs, the serum levels of adiponectin were significantly negatively correlated with the serum levels of large buoyant-, very-low-density lipoprotein, and intermediate-density lipoprotein, as well as small dense low-density lipoprotein (LDL) and significantly positively correlated with large buoyant high-density lipoprotein (HDL). In patients with MS, however, adiponectin was only significantly correlated with the serum levels of phospholipids in total HDL and large buoyant LDL. As revealed through logistic regression and orthogonal partial least-squares discriminant analyses, high adiponectin serum levels were associated with low levels of small dense LDL and high levels of large buoyant HDL in the HVs as well as high levels of large buoyant LDL and total HDL in patients with MS. We conclude that the presence of MS weakens or abolishes the strong associations between adiponectin and the lipoprotein parameters observed in HVs and disturbs the complex interplay between adiponectin and lipoprotein metabolism.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 25, no. 9, 5050
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25095050
URN:NBNurn:nbn:hr:105:205726
Publication2024-05-06
Document URLhttps://www.mdpi.com/1422-0067/25/9/5050
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2025-02-19 14:51:33