prikaz prve stranice dokumenta Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier
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Scientific paper - Review paper
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier
Bone, 141 (2020); 115602. https://doi.org/10.1016/j.bone.2020.115602
Kuber Sampath, T.; Vukičević, Slobodan

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Kuber Sampath, T. & Vukičević, S. (2020). Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier. Bone, 141.. doi: 10.1016/j.bone.2020.115602

Kuber Sampath, T. and Slobodan Vukičević. "Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier." Bone, vol. 141, 2020. https://doi.org/10.1016/j.bone.2020.115602

Kuber Sampath, T. and Slobodan Vukičević. "Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier." Bone 141 (2020). https://doi.org/10.1016/j.bone.2020.115602

Kuber Sampath, T. and Vukičević, S. (2020) 'Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier', Bone, 141. doi: 10.1016/j.bone.2020.115602

Kuber Sampath T, Vukičević S. Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier. Bone [Internet]. 2020 December [cited 2024 December 20];141. doi: 10.1016/j.bone.2020.115602

T. Kuber Sampath and S. Vukičević, "Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier", Bone, vol. 141, December 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:132506. [Accessed: 20 December 2024]

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Metadata
Title (english)Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier
AuthorT. Kuber Sampath
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Anatomy and Clinical Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Anatomy
Abstract (english)
BMPs were purified from demineralized bone matrix based on their ability to induce new bone in vivo and they represent a large member of the TGF-β superfamily of proteins. BMPs serve as morphogenic signals for mesenchymal stem cell migration, proliferation and subsequently differentiation into cartilage and bone during embryonic development. A BMP when implanted with a collagenous carrier in a rat subcutaneous site is capable of inducing new bone by mimicking the cellular events of embryonic bone formation. Based on this biological principle, BMP2 and BMP7 containing collagenous matrix as carrier have been developed as bone graft substitutes for spine fusion and long bone fractures. Here, we describe a novel autologous bone graft substitute that contains BMP6 delivered within an autologous blood coagulum as carrier and summarize the biology of osteogenic BMPs in the context of bone repair and regeneration specifically the critical role that carrier plays to support osteogenesis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBone
Numberingvol. 141, 115602
p-ISSN8756-3282
e-ISSN1873-2763
DOIhttps://doi.org/10.1016/j.bone.2020.115602
URN:NBNurn:nbn:hr:105:132506
Publication2020-12
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S8756328220303823
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-05-03 11:31:15