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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Nature Communications, 10 (2019), 1; 4558. https://doi.org/10.1038/s41467-019-12576-w
Nievergelt, Caroline M.; ...; Jakovljević, Miro; ...

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Nievergelt, C. M. i Jakovljević, M. (2019). International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications, 10. (1). doi: 10.1038/s41467-019-12576-w

Nievergelt, Caroline M. i Miro Jakovljević. "International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci." Nature Communications, vol. 10, br. 1, 2019. https://doi.org/10.1038/s41467-019-12576-w

Nievergelt, Caroline M. i Miro Jakovljević. "International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci." Nature Communications 10, br. 1 (2019). https://doi.org/10.1038/s41467-019-12576-w

Nievergelt, C. M. i Jakovljević, M. (2019) 'International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci', Nature Communications, 10(1). doi: 10.1038/s41467-019-12576-w

Nievergelt CM, Jakovljević M. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications [Internet]. 08.10.2019. [pristupljeno 14.04.2024.];10(1). doi: 10.1038/s41467-019-12576-w

C. M. Nievergelt i M. Jakovljević, "International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci", Nature Communications, vol. 10, br. 1, Listopad 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:991787. [Citirano: 14.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:991787
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Podaci o radu
Naslov (engleski)International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
AutorCaroline M. Nievergelt
Autor
...
AutorMiro Jakovljević
MBZ: 99041
Autor
...
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5-20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson's disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Pregledni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 10, br. 1, 4558
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-019-12576-w
URN:NBNurn:nbn:hr:105:991787
Datum objave publikacije2019-10-08
URL dokumentahttp://www.nature.com/articles/s41467-019-12576-w
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-03-01 09:59:12