Liver re-transplantation for donor-derived neuroendocrine tumor: a case report

Znanstveni rad - Prikaz slučaja

• Autor: Anna Mrzljak
• Autor: Branislav Kocman
• Autor: Anita Škrtić
• Autor: Ivana Furač
• Autor: Jelena Popić
• Autor: Lucija Franušić
• Autor: Renata Žunec
• Autor: Davor Mayer
• Autor: Danko Mikulić
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA INTERNU MEDICINU)
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA SUDSKU MEDICINU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Interna medicina
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Sudska medicina

Sažetak (engleski)

Background: Donor-origin cancer is a well-recognized but rare complication after liver transplantation (LT). The rise in the use of extended criteria donors due to the current shortage of organs increases the risk. Data on donor-origin neuroendocrine neoplasms (NENs) and the most appropriate treatment are scarce. Here, we report a case of a patient who developed a NEN confined to the liver after LT and was treated with liver re-transplantation (re-LT).
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Case summary: A 49-year-old man with no other medical co-morbidities underwent LT in 2013 for alcoholic liver cirrhosis. The donor was a 73-year-old female with no known malignancies. Early after LT, a hypoechogenic (15 mm) lesion was detected in the left hepatic lobe on abdominal ultrasound. The lesion was stable for next 11 mo, when abdominal magnetic resonance identified two hypovascular lesions (20 and 11 mm) with atypical enhancement pattern. Follow-up abdominal ultrasound revealed no new lesions for the next 2.5 years, when magnetic resonance showed a progression in size and number of lesions, also confirmed by abdominal computed tomography. Liver biopsy proved a well-differentiated NEN. Genetic analysis of the NEN confirmed donor origin of the neoplasm. As NEN was confined to liver graft only, in 2018, the patient underwent his second LT. At 12 mo after re-LT the patient is well with no signs of NEN dissemination.
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Conclusion: The benefits of graft explantation should be weighed against the risks of re-LT and the likelihood of NEN dissemination beyond the graft.

• Ključne riječi (engleski): Case report; Donor; Donor-origin tumor; Liver transplantation; Neuroendocrine tumor
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Prikaz slučaja
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: World Journal of Clinical Cases
• Brojčani podaci: vol. 7, br. 18, str. 2794-2801
• p-ISSN: 2307-8960
• DOI: https://doi.org/10.12998/wjcc.v7.i18.2794
• URN:NBN: urn:nbn:hr:105:825464
• Datum objave publikacije: 2019-09-26
• URL dokumenta: https://www.wjgnet.com/2307-8960/full/v7/i18/2794.htm
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-02 10:01:56