prikaz prve stranice dokumenta Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model
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Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model
Bone, 140 (2020); 115544. https://doi.org/10.1016/j.bone.2020.115544
Štoković, Nikola; Ivanjko, Natalia; Pećin, Marko; Erjavec, Igor; Karlović, Sven; Smajlović, Ana; Capak, Hrvoje; Milošević, Milan; Bubić Špoljar, Jadranka; Vnuk, Dražen; Matičić, Dražen; Oppermann, Hermann; Sampath, T. Kuber; Vukičević, Slobodan

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Štoković, N., Ivanjko, N., Pećin, M., Erjavec, I., Karlović, S., Smajlović, A. ... Vukičević, S. (2020). Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model. Bone, 140.. doi: 10.1016/j.bone.2020.115544

Štoković, Nikola, et al. "Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model." Bone, vol. 140, 2020. https://doi.org/10.1016/j.bone.2020.115544

Štoković, Nikola, Natalia Ivanjko, Marko Pećin, Igor Erjavec, Sven Karlović, Ana Smajlović, Hrvoje Capak, et al. "Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model." Bone 140 (2020). https://doi.org/10.1016/j.bone.2020.115544

Štoković, N., et al. (2020) 'Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model', Bone, 140. doi: 10.1016/j.bone.2020.115544

Štoković N, Ivanjko N, Pećin M, Erjavec I, Karlović S, Smajlović A, i sur.. Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model. Bone [Internet]. 11.2020. [pristupljeno 19.12.2024.];140. doi: 10.1016/j.bone.2020.115544

N. Štoković, et al., "Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model", Bone, vol. 140, Studeni 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:435020. [Citirano: 19.12.2024.]

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Naslov (engleski)Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model
AutorNikola Štoković
AutorNatalia Ivanjko
AutorMarko Pećin
AutorIgor Erjavec
AutorSven Karlović
AutorAna Smajlović
AutorHrvoje Capak
AutorMilan Milošević
AutorJadranka Bubić Špoljar
AutorDražen Vnuk
AutorDražen Matičić
AutorHermann Oppermann
AutorT. Kuber Sampath
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Zdravstvena ekologija
Sažetak (engleski)
Posterolateral lumbar fusion (PLF) is a commonly performed surgical procedure for the treatment of pathological conditions of the lumbosacral spine. In the present study, we evaluated an autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (ABC) and synthetic ceramics used as compression resistant matrix (CRM) in the rabbit PLF model. In the pilot PLF rabbit experiment, we tested four different CRMs (BCP 500-1700 μm, BCP 1700-2500 μm and two different TCP in the form of slabs) which were selected based on achieving uniform ABC distribution. Next, ABGS implants composed of 2.5 mL ABC with 0.5 g ceramic particles (TCP or BCP (TCP/HA 80/20) of particle size 500-1700 μm) and 125 μg rhBMP6 (added to blood or lyophilized on ceramics) were placed bilaterally between transverse processes of the lumbar vertebrae (L5-L6) following exposition and decortication in 12 New Zealand White Rabbits observed for 7 weeks following surgery. Spinal fusion outcome was analysed by μCT, palpatory segmental mobility testing and selected specimens were either tested biomechanically (three-point bending test) and/or processed histologically. The total fusion success rate was 90.9% by both μCT analyses and by palpatory segmental mobility testing. The volume of newly formed bone between experimental groups with TCP or BCP ceramics and the different method of rhBMP6 application was comparable. The newly formed bone and ceramic particles integrated with the transverse processes on histological sections resulting in superior biomechanical properties. The results were retrospectively found superior to allograft devitalized mineralized bone as a CRM as reported previously in rabbit PLF. Overall, this novel ABGS containing rhBMP6, ABC and the specific 500-1700 μm synthetic ceramic particles supported new bone formation for the first time and successfully promoted posterolateral lumbar fusion in rabbits.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBone
Brojčani podacivol. 140, 115544
p-ISSN8756-3282
e-ISSN1873-2763
DOIhttps://doi.org/10.1016/j.bone.2020.115544
URN:NBNurn:nbn:hr:105:435020
Datum objave publikacije2020-11
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S8756328220303240
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-04-29 09:11:46