prikaz prve stranice dokumenta Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats
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Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats
Biomedicines, 9 (2021), 10; 1487. https://doi.org/10.3390/biomedicines9101487
Štoković, Nikola; Ivanjko, Natalia; Erjavec, Igor; Breski, Anita; Perć, Mihaela; Vukičević, Slobodan

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Štoković, N., Ivanjko, N., Erjavec, I., Breski, A., Perć, M. i Vukičević, S. (2021). Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats. Biomedicines, 9. (10). doi: 10.3390/biomedicines9101487

Štoković, Nikola, et al. "Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats." Biomedicines, vol. 9, br. 10, 2021. https://doi.org/10.3390/biomedicines9101487

Štoković, Nikola, Natalia Ivanjko, Igor Erjavec, Anita Breski, Mihaela Perć i Slobodan Vukičević. "Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats." Biomedicines 9, br. 10 (2021). https://doi.org/10.3390/biomedicines9101487

Štoković, N., et al. (2021) 'Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats', Biomedicines, 9(10). doi: 10.3390/biomedicines9101487

Štoković N, Ivanjko N, Erjavec I, Breski A, Perć M, Vukičević S. Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats. Biomedicines [Internet]. 16.10.2021. [pristupljeno 05.10.2024.];9(10). doi: 10.3390/biomedicines9101487

N. Štoković, N. Ivanjko, I. Erjavec, A. Breski, M. Perć i S. Vukičević, "Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats", Biomedicines, vol. 9, br. 10, Listopad 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:996950. [Citirano: 05.10.2024.]

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Naslov (engleski)Zoledronate Bound to Ceramics Increases Ectopic Bone Volume Induced by rhBMP6 Delivered in Autologous Blood Coagulum in Rats
AutorNikola Štoković
AutorNatalia Ivanjko
AutorIgor Erjavec
AutorAnita Breski
AutorMihaela Perć
AutorSlobodan Vukičević
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Autologous bone graft substitute (ABGS) containing rhBMP6 in autologous blood coagulum (ABC) with synthetic ceramics is a novel therapeutic solution for bone repair. The aim of this study was to investigate whether the application of Zoledronate (ZOL) with ABGS might enhance the properties of newly formed bone. The effect of ZOL on bone induction was tested in a rat subcutaneous implant model. ZOL bound to synthetic ceramics was added into ABGS implants, and the quantity, quality, and longevity of the induced bone were assessed by micro-CT, histomorphometry, and histology over a period of 365 days. Local use of ZOL in the ABGS implants with ceramics had no influence on the bone volume (BV) on day 14 but subsequently significantly increased BV on days 35, 50, 105, 140, and 365 compared to the control implants. Locally applied ZOL had a similar effect in all of the applied doses (2–20 µg), while its systemic use on stimulating the BV of newly induced bone by ABGS depended on the time of application. BV was increased when ZOL was applied systemically on day 14 but had no effect when applied on day 35. The administration of ZOL bound to ceramics in ABGS increased and maintained the BV over a period of one year, offering a novel bone tissue engineering strategy for treating bone defects and spinal fusions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 9, br. 10, 1487
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines9101487
URN:NBNurn:nbn:hr:105:996950
Datum objave publikacije2021-10-16
ProjektŠifra: KK.01.1.1.01.0008
Naziv (hrvatski): Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platformi i potencijala
Naziv (engleski): Reproductive, and Regenerative Medicine-Exploring New Platforms and Potentials
Kratica: CERRM
Voditelj: Slobodan Vukičević
Pravna nadležnost: eu
Financijer: EK
URL dokumentahttps://www.mdpi.com/2227-9059/9/10/1487
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2022-04-01 11:12:59