prikaz prve stranice dokumenta Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients
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Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients
Journal of Diabetes and its Complications, 29 (2015), 3; 390-394. https://doi.org/10.1016/j.jdiacomp.2014.12.019
Blaslov, Kristina; Bulum, Tomislav; Duvnjak, Lea

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Blaslov, K., Bulum, T. i Duvnjak, L. (2015). Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients. Journal of Diabetes and its Complications, 29. (3), 390-394. doi: 10.1016/j.jdiacomp.2014.12.019

Blaslov, Kristina, et al. "Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients." Journal of Diabetes and its Complications, vol. 29, br. 3, 2015, str. 390-394. https://doi.org/10.1016/j.jdiacomp.2014.12.019

Blaslov, Kristina, Tomislav Bulum i Lea Duvnjak. "Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients." Journal of Diabetes and its Complications 29, br. 3 (2015): 390-394. https://doi.org/10.1016/j.jdiacomp.2014.12.019

Blaslov, K., Bulum, T. i Duvnjak, L. (2015) 'Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients', Journal of Diabetes and its Complications, 29(3), str. 390-394. doi: 10.1016/j.jdiacomp.2014.12.019

Blaslov K, Bulum T, Duvnjak L. Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients. Journal of Diabetes and its Complications [Internet]. 04.2015. [pristupljeno 05.07.2024.];29(3):390-394. doi: 10.1016/j.jdiacomp.2014.12.019

K. Blaslov, T. Bulum i L. Duvnjak, "Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients", Journal of Diabetes and its Complications, vol. 29, br. 3, str. 390-394, Travanj 2015. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:603398. [Citirano: 05.07.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:603398
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Naslov (engleski)Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients
AutorKristina Blaslov
AutorTomislav Bulum
AutorLea Duvnjak
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIM: The pathophysiology of insulin resistance (IR) comprises a complex adipokine mediated cross-talk between white adipose tissue and other organs. Dipeptidyl peptidase-4 (DPP4) is protease recently proposed as a novel adipokine linked to IR. We aimed to assess the relationship between fasting serum DPP4 activityand IR in type 1 diabetic (T1DM) patients. ----- METHODS: A cross-sectional study comprised 44 T1DM patients aged >18 and <65years. IR was esimated using the equation for insulin sensitivity derived from euglycemic-hyperinsulinemic clamp studies-estimated glucose disposal rate (eGDR). DPP4 serum activity was determined spectrophotometrically as a rate of cleavage of 7-Amino-4-Methyl Coumarin (AMC) from H-Gly-Pro-AMC. ----- RESULTS: Patients were divided according to DPP4 activity tertiles (<25.40; ≥36.54 U/L). Fasting serum DPP4 activity was related to disease duration (p=0.012), systolic (p=0.009) and diastolic (p=0.047) blood pressure, waist circumference (p=0.037), urine albumin excretion (p=0.022) and conversely related to eGDR (p=0.004). The linear regression has shown that eGDR decreases for 0.203 mgkg(-1)min(-1) by each increase of serum DPP4 activity of 1 U/L (p<0.001) after adjustment for adjusted for age, gender, disease duration, albuminuria and the use of antihypertensives and statins. ----- CONCLUSION: Serum DPP4 activity is associated with IR in T1DM patients and it might play an important role in its pathophysiology.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaJournal of Diabetes and its Complications
Brojčani podacivol. 29, br. 3, str. 390-394
p-ISSN1056-8727
DOIhttps://doi.org/10.1016/j.jdiacomp.2014.12.019
URN:NBNurn:nbn:hr:105:603398
Datum objave publikacije2015-04
URL dokumentahttps://doi.org/10.1016/j.jdiacomp.2014.12.019
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 08:54:13