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Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes
Diabetologia, 60 (2017), 12; 2352-60. https://doi.org/10.1007/s00125-017-4426-9
Keser, Toma; Gornik, Ivan; Vučković, Frano; Selak, Najda; Pavić, Tamara; Lukić, Edita; Gudelj, Ivan; Gašparović, Hrvoje; Biočina, Bojan; Tilin, Therese; Wennerström, Annika; Männistö, Satu; Salomaa, Veikko; Havulinna, Aki; Wang, Wei; Wilson, James F.; Charutvedi, Nishi; Perola, Markus; Campbell, Harry; Lauc, Gordan; Gornik, Olga Više autora...

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Keser, T., Gornik, I., Vučković, F., Selak, N., Pavić, T., Lukić, E. ... Gornik, O. (2017). Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes. Diabetologia, 60. (12), 2352-60. doi: 10.1007/s00125-017-4426-9

Keser, Toma, et al. "Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes." Diabetologia, vol. 60, br. 12, 2017, str. 2352-60. https://doi.org/10.1007/s00125-017-4426-9

Keser, Toma, Ivan Gornik, Frano Vučković, Najda Selak, Tamara Pavić, Edita Lukić, Ivan Gudelj, et al. "Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes." Diabetologia 60, br. 12 (2017): 2352-60. https://doi.org/10.1007/s00125-017-4426-9

Keser, T., et al. (2017) 'Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes', Diabetologia, 60(12), str. 2352-60. doi: 10.1007/s00125-017-4426-9

Keser T, Gornik I, Vučković F, Selak N, Pavić T, Lukić E, i sur.. Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes. Diabetologia [Internet]. 12.2017. [pristupljeno 15.03.2025.];60(12):2352-60. doi: 10.1007/s00125-017-4426-9

T. Keser, et al., "Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes", Diabetologia, vol. 60, br. 12, str. 2352-60, Prosinac 2017. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:098360. [Citirano: 15.03.2025.]

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Naslov (engleski)Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes
AutorToma Keser
AutorIvan Gornik
AutorFrano Vučković
AutorNajda Selak
AutorTamara Pavić
AutorEdita Lukić
AutorIvan Gudelj
AutorHrvoje Gašparović
AutorBojan Biočina
AutorTherese Tilin
AutorAnnika Wennerström
AutorSatu Männistö
AutorVeikko Salomaa
AutorAki Havulinna
AutorWei Wang
AutorJames F. Wilson
AutorNishi Charutvedi
AutorMarkus Perola
AutorHarry Campbell
AutorGordan Lauc
AutorOlga Gornik
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
AIMS/HYPOTHESIS: Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma N-glycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes. ----- METHODS: Using a chromatographic approach, we analysed N-linked glycans from plasma proteins in two populations comprising individuals with registered hyperglycaemia during critical illness (increased risk for development of type 2 diabetes) and individuals who stayed normoglycaemic during the same condition: AcuteInflammation (59 cases vs 49 controls) and AcuteInflammation Replication (52 cases vs 14 controls) populations. N-glycome was also studied in individuals from FinRisk (37 incident cases of type 2 diabetes collected at baseline vs 37 controls), Orkney Complex Disease Study (ORCADES; 94 individuals with HbA1c > 6.5% [47.5 mmol/mol] vs 658 controls) and Southall and Brent Revisited (SABRE) cohort studies (307 individuals with HbA1c > 6.5% [47.5 mmol/mol] vs 307 controls). ----- RESULTS: Individuals with increased risk for diabetes type 2 development (AcuteInflammation and AcuteInflammation Replication populations), incident cases of type 2 diabetes collected at baseline (FinRisk population) and individuals with elevated HbA1c (ORCADES and SABRE populations) all presented with increased branching, galactosylation and sialylation of plasma protein N-glycans and these changes were of similar magnitude. ----- CONCLUSIONS/INTERPRETATION: Increased complexity of plasma N-glycan structures is associated with higher risk of developing type 2 diabetes and poorer regulation of blood glucose levels. Although further research is needed, this finding could offer a potential new approach for improvement in prevention of diabetes and its complications.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaDiabetologia
Brojčani podacivol. 60, br. 12, str. 2352-60
p-ISSN0012-186X
DOIhttps://doi.org/10.1007/s00125-017-4426-9
URN:NBNurn:nbn:hr:105:098360
Datum objave publikacije2017-12
URL dokumentahttp://doi.org/10.1007/s00125-017-4426-9
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2024-03-28 09:24:36