prikaz prve stranice dokumenta Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors
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Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors
Pathology, Research and Practice, 203 (2007), 11; 779-787. https://doi.org/10.1016/j.prp.2007.07.009
Nikuševa-Martić, Tamara; Beroš, Vili; Pećina-Šlaus, Nives; Pećina, Hrvoje Ivan; Bulić-Jakuš, Floriana

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Nikuševa Martić, T., Beroš, V., Pećina Šlaus, N., Pećina, H. I. i Bulić Jakuš, F. (2007). Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors. Pathology, Research and Practice, 203. (11), 779-787. doi: 10.1016/j.prp.2007.07.009

Nikuševa Martić, Tamara, et al. "Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors." Pathology, Research and Practice, vol. 203, br. 11, 2007, str. 779-787. https://doi.org/10.1016/j.prp.2007.07.009

Nikuševa Martić, Tamara, Vili Beroš, Nives Pećina Šlaus, Hrvoje Ivan Pećina i Floriana Bulić Jakuš. "Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors." Pathology, Research and Practice 203, br. 11 (2007): 779-787. https://doi.org/10.1016/j.prp.2007.07.009

Nikuševa Martić, T., et al. (2007) 'Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors', Pathology, Research and Practice, 203(11), str. 779-787. doi: 10.1016/j.prp.2007.07.009

Nikuševa Martić T, Beroš V, Pećina Šlaus N, Pećina HI, Bulić Jakuš F. Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors. Pathology, Research and Practice [Internet]. 11.2007. [pristupljeno 17.06.2024.];203(11):779-787. doi: 10.1016/j.prp.2007.07.009

T. Nikuševa Martić, V. Beroš, N. Pećina Šlaus, H. I. Pećina i F. Bulić Jakuš, "Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors", Pathology, Research and Practice, vol. 203, br. 11, str. 779-787, Studeni 2007. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:059679. [Citirano: 17.06.2024.]

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Podaci o radu
Naslov (engleski)Genetic changes of CDH1, APC, and CTNNB1 found in human brain tumors
AutorTamara Nikuševa-Martić
AutorVili Beroš
AutorNives Pećina-Šlaus
AutorHrvoje Ivan Pećina
AutorFloriana Bulić-Jakuš
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
This paper focuses on changes in E-cadherin (CDH1), adenomatous polyposis coli (APC), and beta-catenin (CTNNB1) in 50 tumors of the central nervous system. All gene products are components of adherens junctions, but are also involved in wnt signaling. The results of our analysis showed LOH of CDH1 gene in 31% of meningiomas examined (significant correlation; p=0.002). LOH was noted in a single case of germinoma, while other tumor types did not demonstrate any change in CDH1. Fourteen samples (29.2%) with changes in APC gene were observed. The changes were seen in 33.3% of glioblastomas and in 27% of meningiomas; LOH occurred in five informative astocytomas (20%) and in six informative neurinomas (17%). One oligoastrocytoma showed LOH at exon 11, and one medulloblastoma had allelic imbalance at both exons. Five samples (10%) showed heteroduplexes in exon 3 of beta-catenin. Potential mutations were confined to two meningiomas, one astrocytoma, one glioblastoma, and one germinoma. Our results suggest that genetic changes in wnt components are involved in brain tumor genesis. Changes in E-cadherin are involved in meningiomas, while changes in APC gene occur in different tumor types, with glioblastomas showing the highest percentage.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaPathology, Research and Practice
Brojčani podacivol. 203, br. 11, str. 779-787
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2007.07.009
URN:NBNurn:nbn:hr:105:059679
Datum objave publikacije2007-11
URL dokumentahttps://doi.org/10.1016/j.prp.2007.07.009
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-03-28 09:26:37