Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Znanstveni rad - Pregledni rad

• Autor: Dragan Primorac
• Autor: Vilim Molnar
• Autor: Dimitrios Tsoukas
• Autor: Ilona Uzieliene
• Autor: Carlo Tremolada
• Autor: Petar Brlek
• Autor: Emil Klarić
• Autor: Dinko Vidović
• Autor: Marija Zekušić
• Autor: Jolita Pachaleva
• Autor: Eiva Bernotiene
• Autor: Adrian Wilson
• Autor: Ali Mobasheri
• Autorova ustanova: Sveučilište u Zagrebu; Medicinski fakultet; (KATEDRA ZA KIRURGIJU)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Kliničke medicinske znanosti; Kirurgija

Sažetak (engleski)

This review evaluates the current landscape and future directions of regenerative medicine for knee cartilage repair, with a particular focus on tissue engineering strategies. In this context, scaffold-based approaches have emerged as promising solutions for cartilage regeneration. Synthetic scaffolds, while offering superior mechanical properties, often lack the biological cues necessary for effective tissue integration. Natural scaffolds, though biocompatible and biodegradable, frequently suffer from inadequate mechanical strength. Hybrid scaffolds, combining elements of both synthetic and natural materials, present a balanced approach, enhancing both mechanical support and biological functionality. Advances in decellularized extracellular matrix scaffolds have shown potential in promoting cell infiltration and integration with native tissues. Additionally, bioprinting technologies have enabled the creation of complex, bioactive scaffolds that closely mimic the zonal organization of native cartilage, providing an optimal environment for cell growth and differentiation. The review also explores the potential of gene therapy and gene editing techniques, including CRISPR-Cas9, to enhance cartilage repair by targeting specific genetic pathways involved in tissue regeneration. The integration of these advanced therapies with tissue engineering approaches holds promise for developing personalized and durable treatments for knee cartilage injuries and osteoarthritis. In conclusion, this review underscores the importance of continued multidisciplinary collaboration to advance these innovative therapies from bench to bedside and improve outcomes for patients with knee cartilage damage.

• Ključne riječi (engleski): Cartilage, Articular / injuries; Cartilage, Articular / physiology; Genetic Therapy / methods; Genetic Therapy / trends; Humans; Knee Injuries / surgery; Knee Injuries / therapy; Regeneration; Regenerative Medicine / methods; Regenerative Medicine / trends; Tissue Engineering / methods; Tissue Scaffolds
• Jezik: engleski
• Vrsta publikacije: Znanstveni rad - Pregledni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Croatian Medical Journal
• Brojčani podaci: vol. 65, br. 3, str. 268-287
• p-ISSN: 0353-9504
• e-ISSN: 1332-8166
• DOI: https://doi.org/10.3325/cmj.2024.65.268
• URN:NBN: urn:nbn:hr:105:128639
• Datum objave publikacije: 2024
• URL dokumenta: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11157252/
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2024-08-26 08:26:58