prikaz prve stranice dokumenta Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease
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Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease
Neurology International, 15 (2023), 3; 842-856. https://doi.org/10.3390/neurolint15030053
Španić Popovački, Ena; Babić Leko, Mirjana; Langer Horvat, Lea; Brgić, Klara; Vogrinc, Željka; Boban, Marina; Klepac, Nataša; Borovečki, Fran; Šimić, Goran

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Španić Popovački, E., Babić Leko, M., Langer Horvat, L., Brgić, K., Vogrinc, Ž., Boban, M. ... Šimić, G. (2023). Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease. Neurology International, 15. (3), 842-856. doi: 10.3390/neurolint15030053

Španić Popovački, Ena, et al. "Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease." Neurology International, vol. 15, br. 3, 2023, str. 842-856. https://doi.org/10.3390/neurolint15030053

Španić Popovački, Ena, Mirjana Babić Leko, Lea Langer Horvat, Klara Brgić, Željka Vogrinc, Marina Boban, Nataša Klepac, Fran Borovečki i Goran Šimić. "Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease." Neurology International 15, br. 3 (2023): 842-856. https://doi.org/10.3390/neurolint15030053

Španić Popovački, E., et al. (2023) 'Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease', Neurology International, 15(3), str. 842-856. doi: 10.3390/neurolint15030053

Španić Popovački E, Babić Leko M, Langer Horvat L, Brgić K, Vogrinc Ž, Boban M, i sur.. Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease. Neurology International [Internet]. 07.07.2023. [pristupljeno 17.10.2024.];15(3):842-856. doi: 10.3390/neurolint15030053

E. Španić Popovački, et al., "Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease", Neurology International, vol. 15, br. 3, str. 842-856, Srpanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:664041. [Citirano: 17.10.2024.]

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Naslov (engleski)Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer’s Disease
AutorEna Španić Popovački
AutorMirjana Babić Leko
AutorLea Langer Horvat
AutorKlara Brgić
AutorŽeljka Vogrinc
AutorMarina Boban
AutorNataša Klepac
AutorFran Borovečki
AutorGoran Šimić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Sažetak (engleski)
Background: Individuals with specific TREM2 gene variants that encode for a Triggering Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease (AD). By interacting with amyloid and apolipoproteins, the TREM2 receptor regulates the number of myeloid cells, phagocytosis, and the inflammatory response. Higher TREM2 expression has been suggested to protect against AD. However, it is extremely difficult to comprehend TREM2 signaling in the context of AD. Previous results are variable and show distinct effects on diverse pathological changes in AD, differences between soluble and membrane isoform signaling, and inconsistency between animal models and humans. In addition, the relationship between TREM2 and inflammasome activation pathways is not yet entirely understood. Objective: This study aimed to determine the relationship between soluble TREM2 (sTREM2) levels in cerebrospinal fluid (CSF) and plasma samples and other indicators of AD pathology. Methods: Using the Enzyme-Linked Immunosorbent Assay (ELISA), we analyzed 98 samples of AD plasma, 35 samples of plasma from individuals with mild cognitive impairment (MCI), and 11 samples of plasma from healthy controls (HC), as well as 155 samples of AD CSF, 90 samples of MCI CSF, and 50 samples of HC CSF. Results: CSF sTREM2 levels were significantly correlated with neurofibrillary degeneration, cognitive decline, and inflammasome activity in AD patients. In contrast to plasma sTREM2, CSF sTREM2 levels in the AD group were higher than those in the MCI and HC groups. Moreover, concentrations of sTREM2 in CSF were substantially higher in the MCI group than in the HC group, indicating that CSF sTREM2 levels could be used not only to distinguish between HC and AD patients but also as a biomarker to detect earlier changes in the MCI stage. Conclusions: The results indicate CSF sTREM2 levels reliably predict neurofibrillary degeneration, cognitive decline, and inflammasome activation, and also have a high diagnostic potential for distinguishing diseased from healthy individuals. To add sTREM2 to the list of required AD biomarkers, future studies will need to include a larger number of patients and utilize a standardized methodology.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNeurology International
Brojčani podacivol. 15, br. 3, str. 842-856
e-ISSN2035-8377
DOIhttps://doi.org/10.3390/neurolint15030053
URN:NBNurn:nbn:hr:105:664041
Datum objave publikacije2023-07-07
ProjektŠifra: IP-2019-04-3584
Naziv (hrvatski): Uloga krvno-moždane barijere, urođene imunosti i oligomerizacije tau proteina u patogenezi Alzheimerove bolesti
Naziv (engleski): Role of blood-brain barrier, innate immunity, and tau protein oligomerization in the pathogenesis of Alzheimer's disease
Kratica: ALZ-BBB-INNATETAU
Voditelj: Goran Šimić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: KK.01.1.1.01.0007
Naziv (hrvatski): Znanstveni centar izvrsnosti - eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi
Naziv (engleski): Scientific center of excellence - Experimental and clinical research of hypoxic-ischemic brain damage in perinatal and adulthood
Kratica: ZCI-NEURO
Voditelj: Miloš Judaš
Pravna nadležnost: eu
Financijer: Europska komisija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.mdpi.com/2035-8377/15/3/53
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-09-24 09:32:06