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Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization
Pathogens, 13 (2024), 5; 411. https://doi.org/10.3390/pathogens13050411
Bandić Pavlović, Daniela; Pospišil, Mladen; Nađ, Marina; Vrbanović Mijatović, Vilena; Luxner, Josefa; Zarfel, Gernot; Grisold, Andrea; Tonković, Dinko; Dobrić, Mirela; Bedenić, Branka

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Bandić Pavlović, D., Pospišil, M., Nađ, M., Vrbanović Mijatović, V., Luxner, J., Zarfel, G. ... Bedenić, B. (2024). Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization. Pathogens, 13. (5). doi: 10.3390/pathogens13050411

Bandić Pavlović, Daniela, et al. "Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization." Pathogens, vol. 13, br. 5, 2024. https://doi.org/10.3390/pathogens13050411

Bandić Pavlović, Daniela, Mladen Pospišil, Marina Nađ, Vilena Vrbanović Mijatović, Josefa Luxner, Gernot Zarfel, Andrea Grisold, Dinko Tonković, Mirela Dobrić i Branka Bedenić. "Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization." Pathogens 13, br. 5 (2024). https://doi.org/10.3390/pathogens13050411

Bandić Pavlović, D., et al. (2024) 'Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization', Pathogens, 13(5). doi: 10.3390/pathogens13050411

Bandić Pavlović D, Pospišil M, Nađ M, Vrbanović Mijatović V, Luxner J, Zarfel G, i sur.. Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization. Pathogens [Internet]. 15.05.2024. [pristupljeno 14.03.2025.];13(5). doi: 10.3390/pathogens13050411

D. Bandić Pavlović, et al., "Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization", Pathogens, vol. 13, br. 5, Svibanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:722434. [Citirano: 14.03.2025.]

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Podaci o radu
Naslov (engleski)Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization
AutorDaniela Bandić Pavlović
AutorMladen Pospišil
AutorMarina Nađ
AutorVilena Vrbanović Mijatović
AutorJosefa Luxner
AutorGernot Zarfel
AutorAndrea Grisold
AutorDinko Tonković
AutorMirela Dobrić
AutorBranka Bedenić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANESTEZIOLOGIJU, REANIMATOLOGIJU I INTENZIVNU MEDICINU KIRURŠKIH STRUKA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA MEDICINSKU MIKROBIOLOGIJU I PARAZITOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Anesteziologija i reanimatologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Medicinska mikrobiologija
Sažetak (engleski)
Multidrug-resistant (MDR) bacteria of the utmost importance are extended-spectrum β-lactamase (ESBL) and carbapenemase-producing Enterobacterales (CRE), carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Pseudomonas aeruginosa (CRPA), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus spp. (VRE). In this study, an evaluation of MDR bacteria in surgical intensive care units in a tertiary referral hospital was conducted. The study aimed to characterize β-lactamases and other resistance traits of Gram-negative bacteria isolated in surgical intensive care units (ICUs). Disk diffusion and the broth dilution method were used for antibiotic susceptibility testing, whereas ESBL screening was performed through a double disk synergy test and an inhibitor-based test with clavulanic acid. A total of 119 MDR bacterial isolates were analysed. ESBL production was observed in half of the Proteus mirabilis, 90% of the Klebsiella pneumoniae and all of the Enterobacter cloacae and Escherichia coli isolates. OXA-48 carbapenemase, carried by the L plasmid, was detected in 34 K. pneumoniae and one E. coli and Enterobacter cloacae complex isolates, whereas NDM occurred sporadically and was identified in three K. pneumoniae isolates. OXA-48 positive isolates coharboured ESBLs belonging to the CTX-M family in all but one isolate. OXA-23 carbapenemase was confirmed in all A. baumannii isolates. The findings of this study provide valuable insight of resistance determinants of Enterobacterales and A. baumannii which will enhance surveillance and intervention strategies that are necessary to curb the ever-growing carbapenem resistance rates.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 13, br. 5, 411
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens13050411
URN:NBNurn:nbn:hr:105:722434
Datum objave publikacije2024-05-15
URL dokumentahttps://www.mdpi.com/2076-0817/13/5/411
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-02-05 14:25:32