prikaz prve stranice dokumenta Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis
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Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis
Biomedicines, 12 (2024), 4; 750. https://doi.org/10.3390/biomedicines12040750
Sršen, Saša; Held, Martina; Šestan, Mario; Kifer, Nastasia; Kozmar, Ana; Šupe Domić, Daniela; Benzon, Benjamin; Gagro, Alenka; Frković, Marijan; Jelušić, Marija

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Sršen, S., Held, M., Šestan, M., Kifer, N., Kozmar, A., Šupe Domić, D. ... Jelušić, M. (2024). Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis. Biomedicines, 12. (4). doi: 10.3390/biomedicines12040750

Sršen, Saša, et al. "Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis." Biomedicines, vol. 12, br. 4, 2024. https://doi.org/10.3390/biomedicines12040750

Sršen, Saša, Martina Held, Mario Šestan, Nastasia Kifer, Ana Kozmar, Daniela Šupe Domić, Benjamin Benzon, Alenka Gagro, Marijan Frković i Marija Jelušić. "Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis." Biomedicines 12, br. 4 (2024). https://doi.org/10.3390/biomedicines12040750

Sršen, S., et al. (2024) 'Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis', Biomedicines, 12(4). doi: 10.3390/biomedicines12040750

Sršen S, Held M, Šestan M, Kifer N, Kozmar A, Šupe Domić D, i sur.. Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis. Biomedicines [Internet]. 28.03.2024. [pristupljeno 03.03.2025.];12(4). doi: 10.3390/biomedicines12040750

S. Sršen, et al., "Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis", Biomedicines, vol. 12, br. 4, Ožujak 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:419888. [Citirano: 03.03.2025.]

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Naslov (engleski)Serum Levels of S100A8/A9 as a Biomarker of Disease Activity in Patients with IgA Vasculitis
AutorSaša Sršen
AutorMartina Held
AutorMario Šestan
AutorNastasia Kifer
AutorAna Kozmar
AutorDaniela Šupe Domić
AutorBenjamin Benzon
AutorAlenka Gagro
AutorMarijan Frković
AutorMarija Jelušić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
S100A8/A9 protein is a well-known marker of disease activity or severity in many autoimmune and autoinflammatory diseases, but there have not been many studies about the role of S100A8/A9 in IgA vasculitis (IgAV). The aim of our study was to evaluate S100A8/A9 as a possible biomarker of activity in IgAV. We measured the serum levels of S100A8/A9 in pediatric patients with IgA vasculitis at the onset of the disease, after three months, and after six months. We compared these levels between patients with active disease, remission, and a control group, and assessed their correlation with disease activity and other markers of inflammation. Patients with active disease had significantly higher levels of serum S100A8/A9 (median ± SD) than those in the control group at the beginning of the disease (5740 ± 3157 ng/mL vs. 1447 ± 858.3 ng/mL; p < 0.0001), but also three months and six months after disease onset (p < 0.001). There was a positive correlation between S100A8/A9 serum levels and disease activity (p = 0.0003). Patients with active disease had significantly higher levels of S100A8/A9 than those in remission three months after disease onset (p = 0.0260). There was a correlation between S100A8/A9 and C-reactive protein, the C3 component of complement, ferritin, and fibrinogen. Serum levels of S100A8/A9 were also higher in patients with greater skin areas covered with rash. We demonstrated that serum levels of S100A8/A9 correlated well with disease activity and other biomarkers of inflammation in children with IgAV. According to our results, serum S100A8/A9 may be a good indicator of active disease in IgAV.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 12, br. 4, 750
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines12040750
URN:NBNurn:nbn:hr:105:419888
Datum objave publikacije2024-03-28
URL dokumentahttps://www.mdpi.com/2227-9059/12/4/750
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-03 11:40:12