prikaz prve stranice dokumenta Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
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Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
eLife, 13 (2024); e84173. https://doi.org/10.7554/eLife.84173
Moujaes, Flora; Ji, Jie Lisa; Rahmati, Masih; Burt, Joshua B; Schleifer, Charles; Adkinson, Brendan D; Savić, Aleksandar; Santamauro, Nicole; Tamayo, Zailyn; Diehl, Caroline; Kolobaric, Antonija; Flynn, Morgan; Rieser, Nathalie; Fonteneau, Clara; Camarro, Terry; Xu, Junqian; Cho, Youngsun; Repovs, Grega; Fineberg, Sarah K; Morgan, Peter T; Seifritz, Erich; Vollenweider, Franz X; Krystal, John H; Murray, John D; Preller, Katrin H; Anticevic, Alan Više autora...

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Moujaes, F., Ji, J. L., Rahmati, M., Burt, J. B., Schleifer, C., Adkinson, B. D. ... Anticevic, A. (2024). Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. eLife, 13.. doi: 10.7554/eLife.84173

Moujaes, Flora, et al. "Ketamine induces multiple individually distinct whole-brain functional connectivity signatures." eLife, vol. 13, 2024. https://doi.org/10.7554/eLife.84173

Moujaes, Flora, Jie Lisa Ji, Masih Rahmati, Joshua B Burt, Charles Schleifer, Brendan D Adkinson, Aleksandar Savić, et al. "Ketamine induces multiple individually distinct whole-brain functional connectivity signatures." eLife 13 (2024). https://doi.org/10.7554/eLife.84173

Moujaes, F., et al. (2024) 'Ketamine induces multiple individually distinct whole-brain functional connectivity signatures', eLife, 13. doi: 10.7554/eLife.84173

Moujaes F, Ji JL, Rahmati M, Burt JB, Schleifer C, Adkinson BD, i sur.. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. eLife [Internet]. 17.04.2024. [pristupljeno 17.03.2025.];13. doi: 10.7554/eLife.84173

F. Moujaes, et al., "Ketamine induces multiple individually distinct whole-brain functional connectivity signatures", eLife, vol. 13, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:117979. [Citirano: 17.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:117979
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Naslov (engleski)Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
AutorFlora Moujaes
AutorJie Lisa Ji
AutorMasih Rahmati
AutorJoshua B Burt
AutorCharles Schleifer
AutorBrendan D Adkinson
AutorAleksandar Savić
AutorNicole Santamauro
AutorZailyn Tamayo
AutorCaroline Diehl
AutorAntonija Kolobaric
AutorMorgan Flynn
AutorNathalie Rieser
AutorClara Fonteneau
AutorTerry Camarro
AutorJunqian Xu
AutorYoungsun Cho
AutorGrega Repovs
AutorSarah K Fineberg
AutorPeter T Morgan
AutorErich Seifritz
AutorFranz X Vollenweider
AutorJohn H Krystal
AutorJohn D Murray
AutorKatrin H Preller
AutorAlan Anticevic
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects. Methods: We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition. 40 healthy participants received acute ketamine (initial bolus 0.23 mg/kg, continuous infusion 0.58 mg/kg/hr). We quantified resting-state functional connectivity via data-driven global brain connectivity and related it to individual ketamine-induced symptom variation and cortical gene expression targets. Results: We found that: (i) both the neural and behavioral effects of acute ketamine are multi-dimensional, reflecting robust inter-individual variability; (ii) ketamine's data-driven principal neural gradient effect matched somatostatin (SST) and parvalbumin (PVALB) cortical gene expression patterns in humans, while the mean effect did not; and (iii) behavioral data-driven individual symptom variation mapped onto distinct neural gradients of ketamine, which were resolvable at the single-subject level. Conclusions: These results highlight the importance of considering individual behavioral and neural variation in response to ketamine. They also have implications for the development of individually precise pharmacological biomarkers for treatment selection in psychiatry.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaeLife
Brojčani podacivol. 13, e84173
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.84173
URN:NBNurn:nbn:hr:105:117979
Datum objave publikacije2024-04-17
URL dokumentahttps://elifesciences.org/articles/84173
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-06 10:06:20