prikaz prve stranice dokumenta Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer
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Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer
Cancers, 16 (2024), 16; 2916. https://doi.org/10.3390/cancers16162916
Salar, Anamarija; Vuković Đerfi, Kristina; Pačić, Arijana; Škrtić, Anita; Čačev, Tamara; Kapitanović, Sanja

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Salar, A., Vuković Đerfi, K., Pačić, A., Škrtić, A., Čačev, T. i Kapitanović, S. (2024). Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer. Cancers, 16. (16). doi: 10.3390/cancers16162916

Salar, Anamarija, et al. "Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer." Cancers, vol. 16, br. 16, 2024. https://doi.org/10.3390/cancers16162916

Salar, Anamarija, Kristina Vuković Đerfi, Arijana Pačić, Anita Škrtić, Tamara Čačev i Sanja Kapitanović. "Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer." Cancers 16, br. 16 (2024). https://doi.org/10.3390/cancers16162916

Salar, A., et al. (2024) 'Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer', Cancers, 16(16). doi: 10.3390/cancers16162916

Salar A, Vuković Đerfi K, Pačić A, Škrtić A, Čačev T, Kapitanović S. Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer. Cancers [Internet]. 22.08.2024. [pristupljeno 25.03.2025.];16(16). doi: 10.3390/cancers16162916

A. Salar, K. Vuković Đerfi, A. Pačić, A. Škrtić, T. Čačev i S. Kapitanović, "Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer", Cancers, vol. 16, br. 16, Kolovoz 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:290047. [Citirano: 25.03.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:290047
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Podaci o radu
Naslov (engleski)Association of Functional Polymorphisms in MSH3 and IL-6 Pathway Genes with Different Types of Microsatellite Instability in Sporadic Colorectal Cancer
AutorAnamarija Salar
AutorKristina Vuković Đerfi
AutorArijana Pačić
AutorAnita Škrtić
AutorTamara Čačev
AutorSanja Kapitanović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Microsatellite instability (MSI) has been recognized as an important factor in colorectal cancer (CRC). It arises due to deficient mismatch repair (MMR), mostly attributed to MLH1 and MSH2 loss of function leading to a global MMR defect affecting mononucleotide and longer microsatellite loci. Recently, microsatellite instability at tetranucleotide loci, independent of the global MMR defect context, has been suggested to represent a distinct entity with possibly different consequences for tumorigenesis. It arises as a result of an isolated MSH3 loss of function due to its translocation from the nucleus to the cytoplasm under the influence of interleukin-6 (IL-6). In this study the influence of MSH3 and IL-6 signaling pathway polymorphisms (MSH3 exon 1, MSH3+3133A/G, IL-6-174G/C, IL-6R+48892A/C, and gp130+148G/C) on the occurrence of different types of microsatellite instability in sporadic CRC was examined by PCR–RFLP and real-time PCR SNP analyses. A significant difference in distribution of gp130+148G/C genotypes (p = 0.037) and alleles (p = 0.031) was observed in CRC patients with the C allele being less common in tumors with di- and tetranucleotide instability (isolated MSH3 loss of function) compared to tumors without microsatellite instability. A functional polymorphism in gp130 might modulate the IL-6 signaling pathway, directing it toward the occurrence of microsatellite instability corresponding to the IL-6-mediated MSH3 loss of function.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCancers
Brojčani podacivol. 16, br. 16, 2916
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers16162916
URN:NBNurn:nbn:hr:105:290047
Datum objave publikacije2024-08-22
ProjektŠifra: HRZZ-IP-2016-06-1430
Naziv (hrvatski): Mikrosatelitna nestabilnost (MSI i EMAST) u molekularnom profiliranju sporadičnih karcinoma debelog crijeva
Naziv (engleski): Microsatellite instability (MSI and EMAST) in molecular profiling of sporadic colon cancers
Kratica: MSIandEMASTinCRC
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/2072-6694/16/16/2916
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-25 12:44:55