prikaz prve stranice dokumenta MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients
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MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients
International Journal of Molecular Sciences, 25 (2024), 15; 8156. https://doi.org/10.3390/ijms25158156
Fabijanec, Marija; Hulina-Tomašković, Andrea; Štefanović, Mario; Verbanac, Donatella; Ćelap, Ivana; Somborac-Bačura, Anita; Grdić Rajković, Marija; Demirović, Alma; Ramić, Snježana; Krušlin, Božo; Rumora, Lada; Čeri, Andrea; Koržinek, Martha; Petrik, József; Ljubičić, Neven; Baršić, Neven; Barišić, Karmela Više autora...

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Fabijanec, M., Hulina Tomašković, A., Štefanović, M., Verbanac, D., Ćelap, I., Somborac Bačura, A. ... Barišić, K. (2024). MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients. International Journal of Molecular Sciences, 25. (15). doi: 10.3390/ijms25158156

Fabijanec, Marija, et al. "MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients." International Journal of Molecular Sciences, vol. 25, br. 15, 2024. https://doi.org/10.3390/ijms25158156

Fabijanec, Marija, Andrea Hulina Tomašković, Mario Štefanović, Donatella Verbanac, Ivana Ćelap, Anita Somborac Bačura, Marija Grdić Rajković, et al. "MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients." International Journal of Molecular Sciences 25, br. 15 (2024). https://doi.org/10.3390/ijms25158156

Fabijanec, M., et al. (2024) 'MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients', International Journal of Molecular Sciences, 25(15). doi: 10.3390/ijms25158156

Fabijanec M, Hulina Tomašković A, Štefanović M, Verbanac D, Ćelap I, Somborac Bačura A, i sur.. MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients. International Journal of Molecular Sciences [Internet]. 26.07.2024. [pristupljeno 01.04.2025.];25(15). doi: 10.3390/ijms25158156

M. Fabijanec, et al., "MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients", International Journal of Molecular Sciences, vol. 25, br. 15, Srpanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:713889. [Citirano: 01.04.2025.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:713889
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Naslov (engleski)MicroRNA-193a-3p as a Valuable Biomarker for Discriminating between Colorectal Cancer and Colorectal Adenoma Patients
AutorMarija Fabijanec
AutorAndrea Hulina-Tomašković
AutorMario Štefanović
AutorDonatella Verbanac
AutorIvana Ćelap
AutorAnita Somborac-Bačura
AutorMarija Grdić Rajković
AutorAlma Demirović
AutorSnježana Ramić
AutorBožo Krušlin
AutorLada Rumora
AutorAndrea Čeri
AutorMartha Koržinek
AutorJózsef Petrik
AutorNeven Ljubičić
AutorNeven Baršić
AutorKarmela Barišić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Sažetak (engleski)
Specific markers for colorectal cancer (CRC), preceded by colorectal adenoma (pre-CRC), are lacking. This study aimed to investigate whether microRNAs (miR-19a-3p, miR-92a-3p, miR-193a-3p, and miR-210-3p) from tissues and exosomes are potential CRC biomarkers and compare them to existing biomarkers, namely carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9. MiRNA was isolated in the samples of 52 CRC and 76 pre-CRC patients. Expression levels were analyzed by RT-qPCR. When comparing pre-CRC and CRC tissue expression levels, only miR-193a-3p showed statistically significant result (p < 0.0001). When comparing the tissues and exosomes of CRC samples, a statistically significant difference was found for miR-193a-3p (p < 0.0001), miR-19a-3p (p < 0.0001), miR-92a-3p (p = 0.0212), and miR-210-3p (p < 0.0001). A receiver-operating characteristic (ROC) curve and area under the ROC curve (AUC) were used to evaluate the diagnostic value of CEA, CA 19-9, and miRNAs. CEA and CA 19-9 had good diagnostic values (AUCs of 0.798 and 0.668). The diagnostic value only of miR-193a-3p was highlighted (AUC = 0.725). The final logistic regression model, in which we put a combination of CEA concentration and the miR-193a-3p expression level in tissues, showed that using these two markers can distinguish CRC and pre-CRC in 71.3% of cases (AUC = 0.823). MiR-193a-3p from tissues could be a potential CRC biomarker.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 15, 8156
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25158156
URN:NBNurn:nbn:hr:105:713889
Datum objave publikacije2024-07-26
ProjektŠifra: IP-2019-04-4624
Naziv (hrvatski): Gensko, proteinsko i RNA profiliranje kolorektalnog karcinoma primjenom tekuće biopsije
Naziv (engleski): Genetic, Protein and RNA Profiling of Colorectal Cancer Using Liquid Biopsy
Kratica: CRCMolProfil
Voditelj: Karmela Barišić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: KK.01.1.1.02.0021
Naziv (hrvatski): Jačanje znanstveno-istraživačkih i inovacijskih kapaciteta Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu
Naziv (engleski): -
Kratica: FarmInova
Voditelj: Jasmina Lovrić
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: European Regional Development Fund
URL dokumentahttps://www.mdpi.com/1422-0067/25/15/8156
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-31 07:45:16