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Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus
International Journal of Molecular Sciences, 25 (2024), 15; 8064. https://doi.org/10.3390/ijms25158064
Košćak Lukač, Jelena; Bačić Baronica, Koraljka; Šućur, Alan; Sremec, Josip; Tomasović, Sanja; Baronica, Robert; Kelava, Tomislav; Grčević, Danka; Kovačić, Nataša

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Košćak Lukač, J., Bačić Baronica, K., Šućur, A., Sremec, J., Tomasović, S., Baronica, R. ... Kovačić, N. (2024). Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus. International Journal of Molecular Sciences, 25. (15). doi: 10.3390/ijms25158064

Košćak Lukač, Jelena, et al. "Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus." International Journal of Molecular Sciences, vol. 25, br. 15, 2024. https://doi.org/10.3390/ijms25158064

Košćak Lukač, Jelena, Koraljka Bačić Baronica, Alan Šućur, Josip Sremec, Sanja Tomasović, Robert Baronica, Tomislav Kelava, Danka Grčević i Nataša Kovačić. "Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus." International Journal of Molecular Sciences 25, br. 15 (2024). https://doi.org/10.3390/ijms25158064

Košćak Lukač, J., et al. (2024) 'Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus', International Journal of Molecular Sciences, 25(15). doi: 10.3390/ijms25158064

Košćak Lukač J, Bačić Baronica K, Šućur A, Sremec J, Tomasović S, Baronica R, i sur.. Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus. International Journal of Molecular Sciences [Internet]. 24.07.2024. [pristupljeno 01.04.2025.];25(15). doi: 10.3390/ijms25158064

J. Košćak Lukač, et al., "Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus", International Journal of Molecular Sciences, vol. 25, br. 15, Srpanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:711259. [Citirano: 01.04.2025.]

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Podaci o radu
Naslov (engleski)Serum Concentrations of Chemokines CCL20, CXCL8 and CXCL10 in Relapsing-Remitting Multiple Sclerosis and Their Association with Presence of Antibodies against Epstein–Barr Virus
AutorJelena Košćak Lukač
AutorKoraljka Bačić Baronica
AutorAlan Šućur
AutorJosip Sremec
AutorSanja Tomasović
AutorRobert Baronica
AutorTomislav Kelava
AutorDanka Grčević
AutorNataša Kovačić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ANATOMIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Anatomija
Sažetak (engleski)
Epstein–Barr virus (EBV) infection and various chemokines, including CCL20, CXCL8 and CXCL10 are considered to participate in the pathogenesis of multiple sclerosis (MS), and several studies point to a direct regulatory effect of EBV on the expression of these chemokines. In our study we hypothesized that serum concentrations of CCL20, CXCL8 and CXCL0 are induced in patients with relapsing-remitting MS (RRMS) in comparison to healthy individuals, and that they are associated with EBV infection. Serum concentrations of CXCL8 and CXCL10 were lower in RRMS patients in relapse in comparison to healthy controls. Although potential effects of corticosteroid therapy introduced in a subgroup of RRMS patients prior to sampling were excluded by subgroup comparison, this possibility has to be considered while interpreting the results. We found an inverse association between serum concentrations of CXCL8 and anti-Epstein–Barr Virus Nuclear Antigen (EBNA) IgG and decreased expression of CXCL8 in peripheral blood mononuclear cells (PBMC) in relapse compared to remission. Lower serum concentrations of CXCL8 and CXCL10 in RRMS patients and decreased peripheral production of CXCL8 in relapse may indicate compensatory anti-inflammatory counter-regulation in MS.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 25, br. 15, 8064
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms25158064
URN:NBNurn:nbn:hr:105:711259
Datum objave publikacije2024-07-24
ProjektŠifra: UIP-2017-05-1965
Naziv (hrvatski): Uloga Notch signalnog puta u patogenezi jetrene fibroze
Naziv (engleski): The Role of Notch Signalling Pathway in Pathogenesis of Hepatic Fibrosis
Kratica: NOFIBRO
Voditelj: Tomislav Kelava
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Installation Research Projects
ProjektŠifra: IP-2020-02-2431
Naziv (hrvatski): Obnova timusa za preciznu medicinu u liječenju tumora i leukemija
Naziv (engleski): Thymus renewal for precision medicine in cancer and leukaemia treatment
Kratica: THYMINNOVA
Voditelj: Mariastefania Antica
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
URL dokumentahttps://www.mdpi.com/1422-0067/25/15/8064
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2025-03-31 08:01:48