prikaz prve stranice dokumenta Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure
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Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure
European Journal of Gastroenterology & Hepatology, 32 (2020), 11; 1458-1465. https://doi.org/10.1097/MEG.0000000000001667
Grgurević, Ivica; Trkulja, Vladimir; Božin, Tonči; Madir, Anita; Miletić, Maja; Marušić, Srećko; Škrlin, Jasenka; Šestan Crnek, Sandra; Dobrović, Karolina

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Grgurević, I., Trkulja, V., Božin, T., Madir, A., Miletić, M., Marušić, S. ... Dobrović, K. (2020). Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure. European Journal of Gastroenterology & Hepatology, 32. (11), 1458-1465. doi: 10.1097/MEG.0000000000001667

Grgurević, Ivica, et al. "Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure." European Journal of Gastroenterology & Hepatology, vol. 32, br. 11, 2020, str. 1458-1465. https://doi.org/10.1097/MEG.0000000000001667

Grgurević, Ivica, Vladimir Trkulja, Tonči Božin, Anita Madir, Maja Miletić, Srećko Marušić, Jasenka Škrlin, Sandra Šestan Crnek i Karolina Dobrović. "Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure." European Journal of Gastroenterology & Hepatology 32, br. 11 (2020): 1458-1465. https://doi.org/10.1097/MEG.0000000000001667

Grgurević, I., et al. (2020) 'Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure', European Journal of Gastroenterology & Hepatology, 32(11), str. 1458-1465. doi: 10.1097/MEG.0000000000001667

Grgurević I, Trkulja V, Božin T, Madir A, Miletić M, Marušić S, i sur.. Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure. European Journal of Gastroenterology & Hepatology [Internet]. 11.2020. [pristupljeno 13.04.2024.];32(11):1458-1465. doi: 10.1097/MEG.0000000000001667

I. Grgurević, et al., "Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure", European Journal of Gastroenterology & Hepatology, vol. 32, br. 11, str. 1458-1465, Studeni 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:075113. [Citirano: 13.04.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:075113
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Podaci o radu
Naslov (engleski)Infection as a predictor of mortality in decompensated liver cirrhosis: exploring the relationship to severity of liver failure
AutorIvica Grgurević
AutorVladimir Trkulja
AutorTonči Božin
AutorAnita Madir
AutorMaja Miletić
AutorSrećko Marušić
AutorJasenka Škrlin
AutorSandra Šestan Crnek
AutorKarolina Dobrović
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Background: Infections are common in patients with liver cirrhosis and increase mortality. We explored the relationship between infection and liver dysfunction in their effects on mortality. ----- Methods: Single-center data on decompensated liver cirrhosis patients hospitalized between March 2014 and December 2017 (index period) were reviewed until death, liver transplantation or 31 December 2018. Infections were classified as community-acquired infection (CAi) or hospital/healthcare associated infection (HCAi). Child-Pugh, model for the end-stage liver disease (MELD) and chronic liver failure-organ failure (CLiF-OF) scores indicated liver (dys)function. ----- Results: We enrolled 155 patients (85% alcoholic liver disease), 65 without infection at first hospitalization, 48 with CAi and 42 with HCAi. Multidrug resistant agents were confirmed in 2/48 (4.2%) CAi and 10/42 (23.8%) HCAi patients. At first hospitalization, infection was independently associated with worse liver dysfunction and vice versa, and with higher 30-day mortality [odds ratio (OR) = 2.73, 95% confidence interval (CI) 1.07-6.94]. The association was reduced with adjustment for MELD/CLiF-OF scores, but mediation analysis detected an indirect (via liver dysfunction) association. Twenty-eight patients were repeatedly hospitalized, 11 with new HCAi. HCAi was independently associated with twice higher risk of medium-term mortality and added an additional risk to any level of liver dysfunction, considering all or patients who survived the first 30 days. In those repeatedly hospitalized, HCAi appeared independently associated with a higher probability of infection and higher MELD scores at subsequent hospitalizations. ----- Conclusion: Infection (particularly HCAi) adds mortality risk to any level of liver dysfunction in decompensated liver cirrhosis patients. Mechanisms of long(er)-term effects (in acute episode survivors) seemingly include enhanced deterioration of liver function.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaEuropean Journal of Gastroenterology & Hepatology
Brojčani podacivol. 32, br. 11, str. 1458-1465
p-ISSN0954-691X
e-ISSN1473-5687
DOIhttps://doi.org/10.1097/MEG.0000000000001667
URN:NBNurn:nbn:hr:105:075113
Datum objave publikacije2020-11
URL dokumentahttps://journals.lww.com/10.1097/MEG.0000000000001667
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Datum isteka embarga: 2021-12-01
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2021-03-18 10:26:56