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In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
Emergency Medicine International, 2020 (2020); 6805354. https://doi.org/10.1155/2020/6805354
Ložić, Marin; Stambolija, Vasilije; Krezić, Ivan; Dugandžić, Aleksandra; Živanović-Posilović, Gordana; Gojković, Slaven; Kovačević, Josip; Vrdoljak, Luka; Mirković, Ivan; Kokot, Antonio; Petrović, Andreja; Horvat Pavlov, Katarina; Drmić, Domagoj; Šuran, Jelena; Boban Blagaić, Alenka; Seiwerth, Sven; Sikirić, Predrag Više autora...

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Ložić, M., Stambolija, V., Krezić, I., Dugandžić, A., Živanović Posilović, G., Gojković, S. ... Sikirić, P. (2020). In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International, 2020.. doi: 10.1155/2020/6805354

Ložić, Marin, et al. "In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro." Emergency Medicine International, vol. 2020, 2020. https://doi.org/10.1155/2020/6805354

Ložić, Marin, Vasilije Stambolija, Ivan Krezić, Aleksandra Dugandžić, Gordana Živanović Posilović, Slaven Gojković, Josip Kovačević, et al. "In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro." Emergency Medicine International 2020 (2020). https://doi.org/10.1155/2020/6805354

Ložić, M., et al. (2020) 'In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro', Emergency Medicine International, 2020. doi: 10.1155/2020/6805354

Ložić M, Stambolija V, Krezić I, Dugandžić A, Živanović Posilović G, Gojković S, i sur.. In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro. Emergency Medicine International [Internet]. 27.05.2020. [pristupljeno 20.12.2024.];2020. doi: 10.1155/2020/6805354

M. Ložić, et al., "In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro", Emergency Medicine International, vol. 2020, Svibanj 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:489575. [Citirano: 20.12.2024.]

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Naslov (engleski)In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro
AutorMarin Ložić
AutorVasilije Stambolija
AutorIvan Krezić
AutorAleksandra Dugandžić
AutorGordana Živanović-Posilović
AutorSlaven Gojković
AutorJosip Kovačević
AutorLuka Vrdoljak
AutorIvan Mirković
AutorAntonio Kokot
AutorAndreja Petrović
AutorKatarina Horvat Pavlov
AutorDomagoj Drmić
AutorJelena Šuran
AutorAlenka Boban Blagaić
AutorSven Seiwerth
AutorPredrag Sikirić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA TEMELJNU I KLINIČKU FARMAKOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PATOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
Recently, the pentadecapeptide BPC 157-induced counteraction of bupivacaine cardiotoxicity has been reported. Medication includes (i) lidocaine-induced local anesthesia via intraplantar application and axillary and spinal (L4-L5) intrathecal block, (ii) lidocaine-induced arrhythmias, (iii) convulsions, and (iv) lidocaine-induced HEK293 cell depolarisation. BPC 157 applications (intraplantar, intraperitoneal, and intragastric) were given (i) immediately after lidocaine, (ii) 10 min after, or (iii) 5 min before. The BPC 157/NO-system relationship was verified with NO-agents, the NOS-blocker L-NAME and the NOS-substrate L-arginine, given alone and/or together, in axillary and spinal intrathecal blocks. BPC 157 applied immediately after lidocaine or 5 min before the application of lidocaine considerably ameliorated plantar presentation. BPC 157 medication considerably counteracted lidocaine-induced limb function failure; L-NAME was counteracted; L-arginine exhibited counteraction when given immediately after lidocaine, but prolongation was seen when given later. Given together, prophylactically or therapeutically, L-NAME and L-arginine (L-NAME + L-arginine) counteracted the other’s response. BPC 157 maintained its original response when given together with L-NAME or L-arginine. When BPC 157 was given together with L-NAME and L-arginine, its original response reappeared. BPC 157 antagonised the lidocaine-induced bradycardia and eliminated tonic-clonic convulsions. Also, BPC 157 counteracted the lidocaine-induced depolarisation of HEK293 cells. Thus, BPC 157 has antidote activity in its own right against lidocaine and local anesthetics.
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEmergency Medicine International
Brojčani podacivol. 2020, 6805354
p-ISSN2090-2840
e-ISSN2090-2859
DOIhttps://doi.org/10.1155/2020/6805354
URN:NBNurn:nbn:hr:105:489575
Datum objave publikacije2020-05-27
URL dokumentahttps://www.hindawi.com/journals/emi/2020/6805354/
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-03-24 12:10:52