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B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease
Croatian Medical Journal, 62 (2021), 2; 154-164. https://doi.org/10.3325/cmj.2021.62.154
Babić, Antonija; Kurić, Lejla; Zelić Kerep, Ana; Desnica, Lana; Lelas, Antonela; Milošević, Milan; Serventi-Seiwerth, Ranka; Duraković, Nadira; Perić, Zinaida; Mravak Stipetić, Marinka; Bilić, Ervina; Čeović, Romana; Barešić, Marko; Vukić, Tamara; Ljubas Kelečić, Dina; Mazić, Sanja; Bojanić, Ines; Hećimović, Ana; Bilić, Ernest; Zadro, Renata; Vrhovac, Radovan; Pavletić, Steven Z.; Batinić, Drago; Pulanić, Dražen Više autora...

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Babić, A., Kurić, L., Zelić Kerep, A., Desnica, L., Lelas, A., Milošević, M. ... Pulanić, D. (2021). B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease. Croatian Medical Journal, 62. (2), 154-164. doi: 10.3325/cmj.2021.62.154

Babić, Antonija, et al. "B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease." Croatian Medical Journal, vol. 62, br. 2, 2021, str. 154-164. https://doi.org/10.3325/cmj.2021.62.154

Babić, Antonija, Lejla Kurić, Ana Zelić Kerep, Lana Desnica, Antonela Lelas, Milan Milošević, Ranka Serventi Seiwerth, et al. "B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease." Croatian Medical Journal 62, br. 2 (2021): 154-164. https://doi.org/10.3325/cmj.2021.62.154

Babić, A., et al. (2021) 'B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease', Croatian Medical Journal, 62(2), str. 154-164. doi: 10.3325/cmj.2021.62.154

Babić A, Kurić L, Zelić Kerep A, Desnica L, Lelas A, Milošević M, i sur.. B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease. Croatian Medical Journal [Internet]. 30.04.2021. [pristupljeno 19.12.2024.];62(2):154-164. doi: 10.3325/cmj.2021.62.154

A. Babić, et al., "B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease", Croatian Medical Journal, vol. 62, br. 2, str. 154-164, Travanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:284963. [Citirano: 19.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:105:284963
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Podaci o radu
Naslov (engleski)B regulatory cells and monocyte subpopulations in patients with chronic graft-vs-host disease
AutorAntonija Babić
AutorLejla Kurić
AutorAna Zelić Kerep
AutorLana Desnica
AutorAntonela Lelas
AutorMilan Milošević
AutorRanka Serventi-Seiwerth
AutorNadira Duraković
AutorZinaida Perić
AutorMarinka Mravak Stipetić
AutorErvina Bilić
AutorRomana Čeović
AutorMarko Barešić
AutorTamara Vukić
AutorDina Ljubas Kelečić
AutorSanja Mazić
AutorInes Bojanić
AutorAna Hećimović
AutorErnest Bilić
AutorRenata Zadro
AutorRadovan Vrhovac
AutorSteven Z. Pavletić
AutorDrago Batinić
AutorDražen Pulanić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA DERMATOVENEROLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA INTERNU MEDICINU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA NEUROLOGIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PEDIJATRIJU)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA ZDRAVSTVENU EKOLOGIJU, MEDICINU RADA I SPORTA)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Interna medicina
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Neurologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Javno zdravstvo i zdravstvena zaštita
Medicina rada i športa
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Pedijatrija
Sažetak (engleski)
Aim: To assess the correlations of B regulatory cells (Bregs) and monocyte subsets in peripheral blood with the National Institutes of Health (NIH)-consensus-defined clinical manifestations of chronic graft-vs-host disease (cGvHD), in an attempt to establish their role as cellular biomarkers. ----- Methods: This multidisciplinary prospective study enrolled adult cGVHD patients treated in the University Hospital Center Zagreb and University of Zagreb School of Medicine. Immunophenotypic subpopulations of CD24highCD38high Bregs (CD27-, CD27+, and total) and monocyte (classical, intermediate, and non-classical) counts were correlated with demographic, transplant, and cGVHD-related data. Bivariate correlation analysis was performed to evaluate the correlations between Bregs and monocytes subsets and cGVHD organ involvement, as well as cGVHD severity and immunosuppression intensity. ----- Results: Twenty-two adult patients (54.5% female) with cGVHD were enrolled. The median (range) age was 44.5 years (24-65). All patients were transplanted for hematologic malignancies and 40.9% had severe NIH cGVHD global score. The median time from cGVHD diagnosis to the analysis was 16.6 months (0-176). The organ most frequently affected with cGVHD were the eyes (68.2%), skin (45.5%), lungs (45.5%), and liver (40.9%). Lower total and CD27-Bregs counts were correlated with worse cGVHD severity, higher immunosuppression intensity, and lung cGVHD, in terms of cell count, but also with skin cGVHD, in terms of percentages. Patients with liver and joint/fascia cGVHD had a lower percentage of non-classical monocytes and patients with more severe global NIH score had a higher classical monocytes count. ----- Conclusion: Different organs affected by cGVHD are differently associated with different subpopulations of Bregs and monocytes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCroatian Medical Journal
Brojčani podacivol. 62, br. 2, str. 154-164
p-ISSN0353-9504
e-ISSN1332-8166
DOIhttps://doi.org/10.3325/cmj.2021.62.154
URN:NBNurn:nbn:hr:105:284963
Datum objave publikacije2021-04-30
URL dokumentahttp://www.cmj.hr/2021/62/2/33938655.htm
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2021-05-06 08:01:51