prikaz prve stranice dokumenta Heterogeneity of murine periosteum progenitors involved in fracture healing
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Heterogeneity of murine periosteum progenitors involved in fracture healing
eLife, 10 (2021); e58534. https://doi.org/10.7554/eLife.58534
Matthews, Brya G; Novak, Sanja; Sbrana, Francesca V; Funnell, Jessica L; Cao, Ye; Buckels, Emma J; Grčević, Danka; Kalajzić, Ivo

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Matthews, B. G., Novak, S., Sbrana, F. V., Funnell, J. L., Cao, Y., Buckels, E. J. ... Kalajzić, I. (2021). Heterogeneity of murine periosteum progenitors involved in fracture healing. eLife, 10.. doi: 10.7554/eLife.58534

Matthews, Brya G, et al. "Heterogeneity of murine periosteum progenitors involved in fracture healing." eLife, vol. 10, 2021. https://doi.org/10.7554/eLife.58534

Matthews, Brya G, Sanja Novak, Francesca V Sbrana, Jessica L Funnell, Ye Cao, Emma J Buckels, Danka Grčević i Ivo Kalajzić. "Heterogeneity of murine periosteum progenitors involved in fracture healing." eLife 10 (2021). https://doi.org/10.7554/eLife.58534

Matthews, B. G., et al. (2021) 'Heterogeneity of murine periosteum progenitors involved in fracture healing', eLife, 10. doi: 10.7554/eLife.58534

Matthews BG, Novak S, Sbrana FV, Funnell JL, Cao Y, Buckels EJ, i sur.. Heterogeneity of murine periosteum progenitors involved in fracture healing. eLife [Internet]. 09.02.2021. [pristupljeno 02.05.2024.];10. doi: 10.7554/eLife.58534

B. G. Matthews, et al., "Heterogeneity of murine periosteum progenitors involved in fracture healing", eLife, vol. 10, Veljača 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:189659. [Citirano: 02.05.2024.]

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Podaci o radu
Naslov (engleski)Heterogeneity of murine periosteum progenitors involved in fracture healing
AutorBrya G Matthews
AutorSanja Novak
AutorFrancesca V Sbrana
AutorJessica L Funnell
AutorYe Cao
AutorEmma J Buckels
AutorDanka Grčević
AutorIvo Kalajzić
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(HRVATSKI INSTITUT ZA ISTRAŽIVANJE MOZGA)
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA FIZIOLOGIJU I IMUNOLOGIJU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Fiziologija čovjeka
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Neuroznanost
Sažetak (engleski)
The periosteum is the major source of cells involved in fracture healing. We sought to characterize progenitor cells and their contribution to bone fracture healing. The periosteum is highly enriched with progenitor cells, including Sca1+ cells, fibroblast colony-forming units, and label-retaining cells compared to the endosteum and bone marrow. Using lineage tracing, we demonstrate that alpha smooth muscle actin (αSMA) identifies long-term, slow-cycling, self-renewing osteochondroprogenitors in the adult periosteum that are functionally important for bone formation during fracture healing. In addition, Col2.3CreER-labeled osteoblast cells contribute around 10% of osteoblasts but no chondrocytes in fracture calluses. Most periosteal osteochondroprogenitors following fracture can be targeted by αSMACreER. Previously identified skeletal stem cell populations were common in periosteum but contained high proportions of mature osteoblasts. We have demonstrated that the periosteum is highly enriched with skeletal progenitor cells, and there is heterogeneity in the populations of cells that contribute to mature lineages during periosteal fracture healing.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaeLife
Brojčani podacivol. 10, e58534
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.58534
URN:NBNurn:nbn:hr:105:189659
Datum objave publikacije2021-02-09
URL dokumentahttps://elifesciences.org/articles/58534
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2021-09-22 12:39:42