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The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder
Neuroscience Letters, 735 (2020); 135235. https://doi.org/10.1016/j.neulet.2020.135235
Havelka Meštrović, Ana; Tudor, Lucija; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Švob Štrac, Dubravka; Kovačić Petrović, Zrnka; Pivac, Nela

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Havelka Meštrović, A., Tudor, L., Nedić Erjavec, G., Nikolac Perković, M., Švob Štrac, D., Kovačić Petrović, Z. i Pivac, N. (2020). The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder. Neuroscience Letters, 735.. doi: 10.1016/j.neulet.2020.135235

Havelka Meštrović, Ana, et al. "The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder." Neuroscience Letters, vol. 735, 2020. https://doi.org/10.1016/j.neulet.2020.135235

Havelka Meštrović, Ana, Lucija Tudor, Gordana Nedić Erjavec, Matea Nikolac Perković, Dubravka Švob Štrac, Zrnka Kovačić Petrović i Nela Pivac. "The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder." Neuroscience Letters 735 (2020). https://doi.org/10.1016/j.neulet.2020.135235

Havelka Meštrović, A., et al. (2020) 'The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder', Neuroscience Letters, 735. doi: 10.1016/j.neulet.2020.135235

Havelka Meštrović A, Tudor L, Nedić Erjavec G, Nikolac Perković M, Švob Štrac D, Kovačić Petrović Z, i sur.. The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder. Neuroscience Letters [Internet]. 14.09.2020. [pristupljeno 08.11.2024.];735. doi: 10.1016/j.neulet.2020.135235

A. Havelka Meštrović, et al., "The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder", Neuroscience Letters, vol. 735, Rujan 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:105:163321. [Citirano: 08.11.2024.]

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Podaci o radu
Naslov (engleski)The impact of BDNF Val66Met on cognitive skills in veterans with posttraumatic stress disorder
AutorAna Havelka Meštrović
AutorLucija Tudor
AutorGordana Nedić Erjavec
AutorMatea Nikolac Perković
AutorDubravka Švob Štrac
AutorZrnka Kovačić Petrović
AutorNela Pivac
Autorova ustanovaSveučilište u Zagrebu
Medicinski fakultet
(KATEDRA ZA PSIHIJATRIJU I PSIHOLOŠKU MEDICINU)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Psihijatrija
Sažetak (engleski)
Posttraumatic stress disorder (PTSD) is a trauma-induced disorder characterized with impaired cognitive function. BDNF modulates cognition and is involved in neuroprotection and neurocognitive processing. The BDNF Val66Met polymorphism was found to influence cognitive functions. In PTSD, carriers of the BDNF GG genotype had better spatial processing of navigation performance, and lower hyperarousal and startle reaction than A allele carriers. The hypothesis was that veterans with PTSD, carriers of the BDNF Val66Met A allele, will show reduced cognitive skills. The study included 315 male Caucasian combat veterans, with (N = 199) or without (N = 116) current and chronic PTSD. Cognition was assessed using the Rey-Osterrieth Complex Figure (ROCF) test that determines visual-spatial perception and short and long-term visual memory function. The results revealed that cognitive decline measured with ROCF test was associated with PTSD. Presence of the BDNF Val66Met GG genotype in veterans with PTSD, but not in veterans without PTSD, showed protective association with visual short-term memory and visual object manipulation after few seconds (executive function), assessed with the ROCF immediate recall test, compared to the A carriers with PTSD. In conclusion, this was the first study to confirm the association between BDNF Val66Met and memory and attention performed with ROCF in male veterans with PTSD. The results corroborated that the BDNF Val66Met A allele, compared to GG genotype, is associated with poorer short-term visual memory and attention linked with executive functions, in veterans with PTSD.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeZavršna verzija rukopisa prihvaćena za objavljivanje (postprint)
Naslov časopisaNeuroscience Letters
Brojčani podacivol. 735, 135235
p-ISSN0304-3940
e-ISSN1872-7972
DOIhttps://doi.org/10.1016/j.neulet.2020.135235
URN:NBNurn:nbn:hr:105:163321
Datum objave publikacije2020-09-14
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S030439402030505X
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-02-04 09:39:14